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ForumsCompounding & FormulationLyophilization process for peptides — need advice Page 2

Lyophilization process for peptides — need advice

kim_atl_prep Fri, Mar 28, 2025 at 5:05 PM 15 replies 1,430 viewsPage 2 of 3
Dr.PulmRoch
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Mar 28, 2025 at 7:55 PM#6

Correct. If potency preservation is your priority, lyophilized is the way to go. You control the reconstitution, you know exactly when the "clock starts" on degradation, and the dry powder is resilient to shipping temperature issues.

The main advantage of pre-mixed liquid is convenience and not having to do math. For some patients, especially those uncomfortable with reconstitution, that's worth the tradeoff.

32 17rachel_ABQ, traveltech_sara, AttorneyGrant and 29 others
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pete_nash
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Nashville, TN
Mar 28, 2025 at 8:12 PM#7

Been using lyophilized exclusively for 18 months. Wouldn't switch. The reconstitution takes literally 3 minutes and I know my stuff is fresh. Plus I buy larger vials (10mg) and get more doses per vial, which saves money.

The only downside is that I have to buy bac water separately. Minor inconvenience.

Last edited: Mar 29, 2025 at 2:12 AM
14 22Dr.Martinez, mike_mod, SarahChen_PharmD and 11 others
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kate.chem
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Mar 28, 2025 at 8:29 PM#8

One more thing — if you DO go with liquid, try to use it within 28-30 days of opening if possible, even if the BUD says longer. Once you start puncturing the stopper, you introduce contamination risk in addition to the ongoing chemical degradation. Belt and suspenders approach. 🧪

39 22tyler_CSCS, VanRx_Mike, steve_okc and 36 others
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