Should I be worried about my heart rate going up? — what worked for you?

Saw this come across my feed today and thought the community would want to discuss.

Should I be worried about my is something that affects a lot of us here, and the latest information is worth paying attention to. I'll share what I know and hopefully others can fill in the gaps.

Key points as I understand them:

• This has been evolving over the past few months
• There are different perspectives on how to approach it
• The practical implications depend on your specific situation

What are you all hearing from your providers about this? Anyone have direct experience to share?

BiostatsBrad's experience with Should I be worried about resonates deeply with mine. I went through almost the identical process — starting dose, titration timeline, side effects, everything.

The main difference: I titrated faster. But the overall trajectory has been remarkably similar. Down 40 lbs in 5 months.

One thing I would add that BiostatsBrad did not mention: the relationship with food fundamentally changed.

Thanks for sharing this, BiostatsBrad. A few questions about your Should I be worried experience:

1. What dose worked best for you?
2. How long before you noticed appetite suppression kicking in?
3. Did your endo have any specific recommendations about Should I be?

I am in a similar boat and trying to learn from others' experiences before my next appointment.

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Should I be worried about.

To answer TirzTom: yes, I am on compounded sema from a 503B pharmacy.

Quick update: things are still going well. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

Relevant to Should I be worried about my — here is my latest bloodwork comparison:

Key improvements: A1C 8.4% → 5.5%, triglycerides 233 → 103 mg/dL, hsCRP 8.0 → 0.9 mg/L. All on tirzepatide for 13 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.