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Evidence-based GLP-1 & peptide discussion since 2023
ForumsPublic SquareWhen your doctor doesn't believe in GLP-1 therapy — 6 month update Page 2

When your doctor doesn't believe in GLP-1 therapy — 6 month update

JennaRN Fri, Oct 25, 2024 at 6:33 PM 40 replies 2,500 viewsPage 2 of 8
adam_van
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Oct 25, 2024 at 9:23 PM#6

Subscribing to this thread. When your doctor doesn't is exactly what I've been researching. 🙏

31 9FranDenver, Dr.BariatricHTX, LindaRN_retired and 28 others
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Dr.KarenChen
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Oct 25, 2024 at 9:40 PM#7

As a healthcare provider, I want to add some clinical context to this discussion on When your doctor doesn't believe in.

Building on what hank_denver said — the evidence base here is well-established. The key publications to reference are from the SUSTAIN program[1].

Key clinical points:

  1. Efficacy is dose-dependent and typically requires 4-5 weeks to reach steady state
  2. Side effect profile is predictable and usually manageable with standard protocols
  3. Monitoring should include baseline labs and follow-up at 3-month intervals
  4. Patient education significantly improves outcomes and adherence

Standard disclaimer: this is educational, not individualized medical advice.

References:
[1] See thread title for relevant study identification.
Last edited: Oct 26, 2024 at 3:40 AM
34 7JessicaM_2024, TomFromTexas, mike.trainer_LA and 31 others
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TirzTom
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Oct 25, 2024 at 9:57 PM#8

Reading this thread on When your doctor doesn't hits close to home. Night shift nurse — I started at 283 lbs and felt like I would tried everything.

9 months on tirz and I am a different person. Not just the 58 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about When your doctor — take the leap. It was the best health decision I have ever made. ❤️

Last edited: Oct 26, 2024 at 1:57 AM
25 24Dr.EndoIndy, tom_AK, josh_phd_bmore and 22 others
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MounjBrad
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Oct 25, 2024 at 10:14 PM#9

SarahChen_PharmD — that is really helpful context on When your doctor doesn't. Follow-up question: what labs did your doctor order to monitor this?

I am in a similar situation (just started) and trying to set realistic expectations.

23 9pam_columbus, nick_SD_fit, ben_calgary and 20 others
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MASHdoc_SA
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Oct 25, 2024 at 10:31 PM#10

To answer TirzTom's question specifically:

From a clinical standpoint, When your doctor doesn't is an area where we have good evidence.

The short answer: baseline labs + quarterly monitoring is the standard of care.

The longer answer involves understanding the mechanism of action at the receptor level, which I am happy to elaborate on if helpful.

4 19kate.chem, DataDave, Dr.GutHealth and 1 other
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