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Evidence-based GLP-1 & peptide discussion since 2023
ForumsPublic SquareWhen your doctor doesn't believe in GLP-1 therapy — 6 month update Page 5

When your doctor doesn't believe in GLP-1 therapy — 6 month update

JennaRN Fri, Oct 25, 2024 at 6:33 PM 40 replies 2,500 viewsPage 5 of 8
kim_atl_prep
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Oct 26, 2024 at 1:38 AM#21

DoseLogDan — that is really helpful context on When your doctor doesn't. Follow-up question: what labs did your doctor order to monitor this?

I am in a similar situation (just started) and trying to set realistic expectations.

37 17PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 34 others
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NurseKim_ATL
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Atlanta, GA
Oct 26, 2024 at 1:55 AM#22

To answer greg_boulder's question specifically:

From a clinical standpoint, When your doctor doesn't is an area where we have good evidence.

The short answer: baseline labs + quarterly monitoring is the standard of care.

The longer answer involves understanding the mechanism of action at the receptor level, which I am happy to elaborate on if helpful.

25 12raj_cambridge, ingrid_STO, pete_nash and 22 others
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PurityPaulOR
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Oct 26, 2024 at 2:12 AM#23

Thank you kim_atl_prep! This is incredibly helpful. Bookmarking for later. 🙏

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PharmacoVig_BOS
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Boston, MA
Oct 26, 2024 at 2:29 AM#24

Relevant to When your doctor doesn't — here is my latest bloodwork comparison:

Key improvements: A1C 8.4% → 5.5%, triglycerides 249 → 119 mg/dL, hsCRP 8.0 → 1.3 mg/L. All on tirzepatide for 17 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

Last edited: Oct 26, 2024 at 5:29 AM
38 2kate.chem, DataDave, Dr.GutHealth and 35 others
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dave_SLC
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Salt Lake City, UT
Oct 26, 2024 at 2:46 AM#25

Slightly tangential to When your doctor doesn't but kim_atl_prep reminded me — what is the latest on the oral formulations?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

32 22Dr.BariatricHTX, LindaRN_retired, tommy_boulder and 29 others
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