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Evidence-based GLP-1 & peptide discussion since 2023
Forumsβ€ΊPublic Squareβ€ΊHas anyone dealt with week 3 update - feeling like garbage tbh?

Has anyone dealt with week 3 update - feeling like garbage tbh?

PurityPaulOR Thu, Aug 29, 2024 at 4:24 AM 10 replies 1,683 viewsPage 1 of 2
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PurityPaulOR
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Aug 29, 2024 at 5:49 AM#1

Hot take incoming: has anyone dealt with week 3.

I know this is controversial here but I think the conventional wisdom on this topic might be overly simplistic. Before you grab your pitchforks, hear me out.

My argument is based on conversations with my provider who has a different perspective.

Change my mind. Seriously β€” I want to be wrong about this if I am.

33 5Dr.LeslieOBGYN, MikeNYC_runner and 30 others
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PharmacoVig_BOS
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Aug 29, 2024 at 6:06 AM#2

Good question. For Has anyone dealt with week 3 update, here is what the evidence says:

  • The clinical trial data (SELECT program) supports this approach
  • Real-world results from this community generally confirm the trial findings
  • Individual variation is real β€” give it at least 8 weeks before judging

Happy to go deeper on any of these points if helpful.

Last edited: Aug 29, 2024 at 9:06 AM
28 9Dr.GutHealth, amsterdam_pete, LondonLisa and 25 others
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BrianDallas92
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Aug 29, 2024 at 6:23 AM#3
PharmacoVig_BOS said:
For Has anyone dealt with week 3 update, here is what the evidence says:The clinical trial data (SEL

Completely agree with PharmacoVig_BOS. I would add that Has anyone dealt with week 3 also has implications for body composition that sometimes get overlooked in these discussions.

In my case, following a similar approach led to fewer side effects compared to what I was doing before.

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sarah_nash92
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Aug 29, 2024 at 6:40 AM#4

Agreed. My doctor said the same thing about Has anyone dealt.

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Dr.ObesityLA
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Aug 29, 2024 at 6:57 AM#5

As a healthcare provider, I want to add some clinical context to this discussion on Has anyone dealt with week 3 update -.

Building on what PurityPaulOR said β€” the evidence base here is well-established. The key publications to reference are from the SELECT program[1].

Key clinical points:

  1. Efficacy is dose-dependent and typically requires 4-5 weeks to reach steady state
  2. Side effect profile is predictable and usually manageable with standard protocols
  3. Monitoring should include baseline labs and follow-up at 3-month intervals
  4. Patient education significantly improves outcomes and adherence

Standard disclaimer: this is educational, not individualized medical advice.

References:
[1] See thread title for relevant study identification.
Last edited: Aug 29, 2024 at 7:57 AM
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