Dr.DermMIA — that is really helpful context on Orforglipron ATTAIN-4 . Follow-up question: what labs did your doctor order to monitor this?
I am in a similar situation (just started) and trying to set realistic expectations.
To answer LarryQC_SD's question specifically:
From a clinical standpoint, Orforglipron ATTAIN-4 is an area where we have good evidence.
The short answer: baseline labs + quarterly monitoring is the standard of care.
The longer answer involves understanding the mechanism of action at the receptor level, which I am happy to elaborate on if helpful.
Thank you Dr.RheumBOS! This is incredibly helpful. Bookmarking for later. 🙏
Community-driven peptide testing and vendor rating platform. Transparent results. Unbiased analysis. Trusted by thousands.
View ResultsRelevant to Orforglipron ATTAIN-4 — here is my latest bloodwork comparison:
Key improvements: A1C 7.6% → 5.5%, triglycerides 209 → 109 mg/dL, hsCRP 8.0 → 0.9 mg/L. All on tirzepatide for 13 months.
The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.
Slightly tangential to Orforglipron ATTAIN-4 but Dr.RheumBOS reminded me — what is the latest on the oral formulations?
I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.