🍪 CompoundTalk uses cookies to improve your experience, analyze traffic, and personalize content. By continuing to use this site, you agree to our Cookie Policy.
Evidence-based GLP-1 & peptide discussion since 2023
ForumsTirzepatide (Mounjaro / Zepbound)Has anyone dealt with tirzepatide and fatty liver? Page 2

Has anyone dealt with tirzepatide and fatty liver?

Dr.PeteFamMed Sat, Aug 23, 2025 at 6:29 PM 39 replies 1,964 viewsPage 2 of 8
BiostatsBrad
Member
456
2,345
Jul 2024
Durham, NC
Aug 23, 2025 at 9:19 PM#6

Nate — 1,200 cal/day is definitely too low, especially if you're male. Please talk to your provider or a dietitian. Under-eating on GLP-1s can cause muscle loss and metabolic adaptation that'll hurt you long-term. We want fat loss, not just weight loss. 💪

44 2LindaRN_retired, tommy_boulder, hyun_seoul and 41 others
Reply Quote Save Share Report
RunnerRach
Member
467
2,123
Aug 2024
Boston, MA
Aug 23, 2025 at 9:36 PM#7

The energy thing is real and I think it's one of the most underreported benefits of tirz. I track my workouts religiously and my performance has IMPROVED since starting, despite being in a caloric deficit. My lifting numbers went up. That should not happen when you're eating less. There's definitely something pharmacological going on beyond just "eating better."

I've seen some hypotheses that GIP receptor activation in muscle tissue may help preserve or even improve muscle glucose utilization during weight loss. Would love to see more research on this.

47 21MikeKY_noInsulin, Dr.RaviCardio, jennifer_SEA and 44 others
Reply Quote Save Share Report
chris_chi24
Member
389
1,678
Sep 2024
Chicago, IL
Aug 23, 2025 at 9:53 PM#8

Fran that's fascinating. I'm not lifting (yet) but I might start — the energy has to go somewhere right? 😂

Thanks everyone for confirming I'm not losing my mind. Just losing weight and gaining energy. I'll take it!

11 13MaxMetOK, MounjBrad, nick_newbie and 8 others
Reply Quote Save Share Report

Sigma-Aldrich — Research-Grade Standards

Certified reference materials, analytical reagents, and research-grade standards for peptide verification. Trusted by laboratories worldwide.

Shop Reference Standards

Similar Threads

SURMOUNT-5: Tirzepatide vs semaglutide head-to-head — full results11 replies
SURPASS 1-5 program: tirzepatide T2DM efficacy data compilation6 replies
Tirzepatide dual agonism: GIP + GLP-1 synergistic mechanism18 replies
5mg → 10mg → 15mg titration — clinical guidance and real-world data8 replies
Zepbound insurance coverage — payer-by-payer breakdown 20268 replies
ForumsNewTrendingMembersAccount

Log In

Forgot password?
No account? Register