🍪 CompoundTalk uses cookies to improve your experience, analyze traffic, and personalize content. By continuing to use this site, you agree to our Cookie Policy.
Evidence-based GLP-1 & peptide discussion since 2023
ForumsCompounding & FormulationIs it normal for the powder to not fully dissolve — my results so far

Is it normal for the powder to not fully dissolve — my results so far

FitDadDave Wed, Nov 27, 2024 at 3:59 PM 9 replies 1,594 viewsPage 1 of 2
This thread is more than 15 months old. Information may be outdated. Consider searching for more recent discussions.
FitDadDave
Member
534
2,678
Jul 2024
Minneapolis, MN
Nov 27, 2024 at 5:24 PM#1
Most testing discussion focuses on Janoshik, but I've been using Finnrick Labs for my peptide analysis. They're a US-based analytical lab that offers HPLC peptide testing. Wanted to share my GGPeps semaglutide results. Tested 3 separate GGPeps semaglutide batches: Batch 1 — GGS-2025-442 (October 2025 order) - Identity: ✅ Confirmed Semaglutide - Purity (HPLC): 96.3% - Major impurity: 2.1% (likely des-amino semaglutide variant) - Minor impurities: 1.6% combined Batch 2 — GGS-2025-518 (December 2025 order) - Identity: ✅ Confirmed Semaglutide - Purity (HPLC): 97.1% - Major impurity: 1.8% - Minor impurities: 1.1% combined Batch 3 — GGS-2026-029 (February 2026 order) - Identity: ✅ Confirmed Semaglutide - Purity (HPLC): 95.8% - Major impurity: 2.4% - Minor impurities: 1.8% combined Average across 3 batches: 96.4% For reference, I've also tested QSC semaglutide at Finnrick — one batch came back at 95.1%. So GGPeps is performing at least comparably on sema. Finnrick testing costs $95/sample for the basic peptide identity + purity panel. Turnaround was 8-12 business days. They accept samples by mail. Subjective experience: I ran GGPeps sema at 0.5mg/week for 12 weeks. Lost 19 lbs with moderate appetite suppression. Consistent with expected results for pharmaceutical semaglutide at that dose. No unusual side effects beyond mild nausea in weeks 1-2. Bottom line: GGPeps semaglutide is legitimate product with purity in the mid-to-high 90s range. 🔬
4 15Dr.NephBHM_UK, kim_atl_prep, sarah_TO and 1 other
Reply Quote Save Share Report
Dr.GastroMayo
VIP Member
2,345
13,456
Jan 2024
Mayo Clinic, MN
Nov 27, 2024 at 5:41 PM#2
Interesting to see Finnrick results. I wasn't familiar with them. A few questions: 1. Are they ISO accredited? 2. Do they publish their testing methodology (column type, mobile phase, gradient)? 3. Have you cross-validated by sending the same sample to both Finnrick and Janoshik? Not questioning your results — just want to understand the lab's credibility compared to Janoshik which has become the de facto standard in this community.
1 10VendorMark
Reply Quote Save Share Report
JenPlateau
Member
234
890
Nov 2024
Missouri
Nov 27, 2024 at 5:58 PM#3
Good questions: 1. Finnrick is CLIA-certified and ISO 17025 accredited for analytical chemistry, yes. 2. They use C18 reversed-phase HPLC with UV detection at 220nm. They'll send the full method details if you request them with your results. 3. I haven't done a cross-validation yet but that's a great idea. I'll send from my next order to both labs and compare. Would be fascinating to see how closely they agree. The advantage of Finnrick is they're US-based so shipping samples is faster and cheaper (no international postage). Turnaround is comparable to Janoshik. The slight disadvantage is they have less community history so fewer people know about them.
48 21RunnerRach, TrialNerd_Beth, HPLC_Greg and 45 others
Reply Quote Save Share Report

PeptideMeter — Independent Peptide Analytics

Community-driven peptide testing and vendor rating platform. Transparent results. Unbiased analysis. Trusted by thousands.

View Results
Dr.LeslieOBGYN
Member
567
2,567
May 2024
Dallas, TX
Nov 27, 2024 at 6:15 PM#4
As a pharmacist, I can put these numbers in context: - Branded Ozempic (Novo Nordisk) specifies ≥95% purity in their FDA submission - Most compounding pharmacies target 90-110% of labeled potency (wider range than you'd think) - The FDA's 503B guidance requires compounded semaglutide to test between 90-110% GGPeps averaging 96.4% puts them solidly in the pharmaceutical-grade range. The 95.8% lowest result is still above the FDA's own threshold for branded product. The impurity profile is also normal. Des-amino variants and oxidized forms are expected synthesis byproducts. At <3% total, this is clean product. One thing I'd note: semaglutide is inherently harder to synthesize at ultra-high purity compared to simpler peptides because of the C18 fatty acid sidechain. Getting 96%+ consistently is genuinely impressive for any non-Novo Nordisk manufacturer. 💊
4 11NicoleRaleigh, james_edin, FranDenver and 1 other
Reply Quote Save Share Report
ricardo_MIA
Member
378
1,678
Sep 2024
Miami, FL
Nov 27, 2024 at 6:32 PM#5
How much are GGPeps sema vials running these days? Last I checked they were $35 for 5mg vials. At 0.5mg/week that's $3.50/week or about $15/month for a medication that costs $900+/month retail. Even with the $95 testing cost factored in, the value proposition is insane. I've been doing QSC sema at $22/vial but I'm intrigued by GGPeps after seeing these purity numbers. The slight premium might be worth it for arguably better sema quality.
Last edited: Nov 27, 2024 at 11:32 PM
26 23ChrisMacros, KetoKyle, CanadaChris and 23 others
Reply Quote Save Share Report

Similar Threads

503A vs 503B compounding — regulatory framework explained4 replies
Compounded semaglutide stability: accelerated degradation study results6 replies
Lyophilized vs liquid peptides — stability and bioavailability comparison18 replies
Bacteriostatic water sourcing and sterility considerations8 replies
State-by-state compounding pharmacy regulations — 2026 map8 replies
ForumsNewTrendingMembersAccount

Log In

Forgot password?
No account? Register