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ForumsTirzepatide (Mounjaro / Zepbound)Tirzepatide nausea management — anyone have experience? Page 2

Tirzepatide nausea management — anyone have experience?

hank_denver Wed, Jul 2, 2025 at 12:21 AM 9 replies 1,291 viewsPage 2 of 2
Dr.AddMedPHL
Senior Member
1,234
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Mar 2024
Philadelphia, PA
Jul 2, 2025 at 3:11 AM#6

Nate — 1,200 cal/day is definitely too low, especially if you're male. Please talk to your provider or a dietitian. Under-eating on GLP-1s can cause muscle loss and metabolic adaptation that'll hurt you long-term. We want fat loss, not just weight loss. 💪

14 24FitDadDave, RunnerRach, TrialNerd_Beth and 11 others
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dan_philly
Member
456
2,123
Jul 2024
Philadelphia, PA
Jul 2, 2025 at 3:28 AM#7

The energy thing is real and I think it's one of the most underreported benefits of tirz. I track my workouts religiously and my performance has IMPROVED since starting, despite being in a caloric deficit. My lifting numbers went up. That should not happen when you're eating less. There's definitely something pharmacological going on beyond just "eating better."

I've seen some hypotheses that GIP receptor activation in muscle tissue may help preserve or even improve muscle glucose utilization during weight loss. Would love to see more research on this.

22 18AmyNC_wife, SkepticalSean, Dr.CardioMD and 19 others
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roxy_nash
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890
Dec 2024
Nashville, TN
Jul 2, 2025 at 3:45 AM#8

Fran that's fascinating. I'm not lifting (yet) but I might start — the energy has to go somewhere right? 😂

Thanks everyone for confirming I'm not losing my mind. Just losing weight and gaining energy. I'll take it!

30 16tony_orlando, Dr.NephBHM_UK, kim_atl_prep and 27 others
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