SOUL trial preliminary data — 6 month update — Page 2 | Cardiovascular Outcomes

Dr.ObesityMed

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Aug 1, 2025 at 11:24 PM#6

sarah.morrison said:
Short answer: it depends on your starting point

Gonna push back on this one. SOUL trial preliminary data 6 is not that straightforward in my experience. I have been on this for 12 months and the reality is messier than the trials suggest.

Don't get me wrong — the medication works. But cost accessibility is a real barrier. We should be honest about that.

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josh_phd_bmore

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Baltimore, MD

Aug 1, 2025 at 11:41 PM#7

Adding my data to this SOUL trial preliminary discussion:

Metric	Baseline	Month 3	Month 6
Weight	256 lbs	216 lbs	201 lbs
A1C	7.0%	5.8%	5.2%
hsCRP	5.0	2.0	0.6

Protocol: Semaglutide 2.4mg/wk, resistance training 3x/wk, protein 1.3g/kg/day.

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matt_MKE

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Milwaukee, WI

Aug 1, 2025 at 11:58 PM#8

julia.endo — wow. This community is amazing.

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fiona_VT

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Vermont

Aug 2, 2025 at 12:15 AM#9

Slightly tangential to SOUL trial preliminary but JenPlateau reminded me — what is the latest on the oral formulations?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

Last edited: Aug 2, 2025 at 1:15 AM

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