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Evidence-based GLP-1 & peptide discussion since 2023
ForumsLab Results & BiomarkersLiver enzymes trending down on GLP-1 — ALT/AST normalization Page 3

Liver enzymes trending down on GLP-1 — ALT/AST normalization

MASHdoc_SA Thu, Mar 12, 2026 at 5:07 PM 17 replies 389 viewsPage 3 of 4
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Mar 12, 2026 at 9:22 PM#11

Moderator note: Great discussion, everyone. Just a reminder to keep things civil and evidence-based.

Thread quality is excellent — keep it up. 👍

4 5PedsEndoPhilly, SleepDoc_PDX, RegAffairsDC and 1 other
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mike_nyc
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Mar 12, 2026 at 9:39 PM#12

Slightly tangential to Liver enzymes trending but PharmD_Rodriguez reminded me — has the insurance landscape changed recently?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

Last edited: Mar 13, 2026 at 1:39 AM
35 14stefan_berlin, Dr.EM_Chicago, pete_RVA and 32 others
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JessicaM_2024
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Mar 12, 2026 at 9:56 PM#13
maria_elpaso said:
Follow-up question: what labs did your doctor order to monitor this

This is exactly right. maria_elpaso articulated what I have been trying to explain to my friends for months. The Liver enzymes trending aspect is what made the difference for me.

Last edited: Mar 12, 2026 at 10:56 PM
18 2mike_mealprep, NicoleRaleigh, james_edin and 15 others
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jennifer_SEA
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Mar 12, 2026 at 10:13 PM#14

Saving this for reference. Quality thread.

22 14jim_asheville, matt_MKE, Dr.ReproEndo and 19 others
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NicoleRaleigh
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Mar 12, 2026 at 10:30 PM#15

Adding my data to this Liver enzymes trending discussion:

MetricBaselineMonth 4Month 6
Weight276 lbs226 lbs211 lbs
A1C7.0%6.2%5.2%
hsCRP5.03.01.0

Protocol: Tirzepatide 15mg/wk, resistance training 3x/wk, protein 1.3g/kg/day.

38 3mike_nyc, VendorMark, COA_Karl and 35 others
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