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ForumsPublic SquareComparative pharmacokinetics: semaglutide vs tirzepatide vs retatrutide — need advice Page 6

Comparative pharmacokinetics: semaglutide vs tirzepatide vs retatrutide — need advice

emily_PDX Fri, Apr 26, 2024 at 4:07 PM 36 replies 2,470 viewsPage 6 of 8
stefan_berlin
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Apr 27, 2024 at 12:37 AM#26

Following this thread closely. Comparative is something I'm actively working through.

13 17NeuroNate, JessicaH_TX, KevinCompounds and 10 others
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DebRD_ATL
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Apr 27, 2024 at 12:54 AM#27
ZaraB_AL said:
Dad of 2 checking in — I started at 273 lbs and felt like I would tried everything

I respect ZaraB_AL perspective but I think this oversimplifies things a bit. Re: Comparative pharmacokinetics — the subgroup analyses show meaningful heterogeneity.

I am not saying ZaraB_AL wrong entirely — just that the picture is more nuanced than a blanket statement. The SURMOUNT data specifically shows baseline BMI-dependent responses.

32 9RegAffairsDC, BiostatsBrad, PeptideSynthNJ and 29 others
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NeuroNate
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Chicago, IL
Apr 27, 2024 at 1:11 AM#28

Reading this thread on Comparative hits close to home. Night shift nurse — I started at 299 lbs and felt like I would tried everything.

15 months on tirz and I am a different person. Not just the 74 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about Comparative — take the leap. It was the best health decision I have ever made. ❤️

32 6sarah_TO, wendy_avl, jason_paloalto and 29 others
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SteveThurs
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Sep 2024
Wisconsin
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Apr 27, 2024 at 1:28 AM#29

Bookmarked 📌 The Comparative info in this thread is essential. Coming back to this for sure.

Last edited: Apr 27, 2024 at 5:28 AM
12 12DoseLogDan, SleepFixSam, PurityPaulOR and 9 others
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bri_stats
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May 2024
Seattle, WA
Apr 27, 2024 at 1:45 AM#30

stefan_berlin — that is really helpful context on Comparative. Follow-up question: did you change anything about your diet at the same time?

I am in a similar situation (month 2) and trying to set realistic expectations.

38 5julia.endo, JessicaM_2024, TomFromTexas and 35 others
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