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ForumsTirzepatide (Mounjaro / Zepbound)5mg doing nothing - should I ask to go up? — need advice Page 3

5mg doing nothing - should I ask to go up? — need advice

Dr.LeslieOBGYN Sat, Jun 7, 2025 at 12:56 PM 12 replies 1,308 viewsPage 3 of 3
Dr.EndoIndy
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Oct 2024
Indianapolis, IN
Jun 7, 2025 at 5:11 PM#11

+1 to sarah.morrison. Especially the point about "Re: 5mg doing nothing - should I — the s..." — I have seen the same in my own experience with 5mg doing nothing -.

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WendyG_ATL
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Apr 2024
Georgia
Jun 7, 2025 at 5:28 PM#12

Want to share my personal experience related to 5mg doing nothing - should I since I think it might help others in a similar situation.

I started my GLP-1 journey in March 2025 at 285 lbs with metabolic syndrome. My telehealth provider prescribed semaglutide 0.25mg to start.

Now, 8 months later: I am down 65 lbs, my labs have normalized, and my sleep apnea has improved dramatically. The 5mg doing nothing - aspect specifically was something that made a big difference in my journey.

This forum was my go-to resource throughout.

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carlos_SATX
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Oct 2024
San Antonio, TX
Jun 7, 2025 at 5:45 PM#13

PedsEndoPhilly — that is really helpful context on 5mg doing nothing -. Follow-up question: did you change anything about your diet at the same time?

I am in a similar situation (month 2) and trying to set realistic expectations.

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pat_auckland
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Jun 2024
Auckland, NZ
Jun 7, 2025 at 6:02 PM#14

To answer WendyG_ATL's question specifically:

From a clinical standpoint, 5mg doing nothing - should I is well-supported by the literature.

The short answer: follow the standard titration protocol and reassess at 4-6 weeks.

The longer answer involves pharmacokinetic considerations around steady-state concentrations, which I am happy to elaborate on if helpful.

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emily_PDX
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Nov 2024
Portland, OR
Jun 7, 2025 at 6:19 PM#15

Saving this for reference. Top-tier content.

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