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Evidence-based GLP-1 & peptide discussion since 2023
ForumsCardiovascular OutcomesHas anyone dealt with tirzepatide cardiovascular safety? Page 3

Has anyone dealt with tirzepatide cardiovascular safety?

carlos_SATX Mon, Jun 23, 2025 at 10:20 PM 41 replies 1,657 viewsPage 3 of 9
raj_cambridge
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Jun 2024
Cambridge, MA
Jun 24, 2025 at 2:35 AM#11

Thank you TrialTracker_MD! This is incredibly helpful. Taking this to my next appointment. 🙏

1 20SleepFixSam
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wei_SG
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Nov 2024
Singapore, SG
Jun 24, 2025 at 2:52 AM#12

Slightly tangential to Has anyone dealt with but carlos_SATX reminded me — does anyone have experience combining this with metformin?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

34 23SaraMom3, Dr.MetabolicMD, RetaRick_CA and 31 others
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sarah_nash92
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Jun 2024
Nashville, TN
Jun 24, 2025 at 3:09 AM#13

Thanks for sharing this, carlos_SATX. A few questions about your Has anyone dealt experience:

  1. What dose did you start at?
  2. How long before you noticed side effects improving?
  3. Did your provider have any specific recommendations about Has anyone deal?

I am in a similar boat and trying to learn from others' experiences before my next appointment.

Last edited: Jun 24, 2025 at 9:09 AM
29 4ZaraB_AL, JakeSmashed95, NauseaFreeNow and 26 others
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carlos_SATX
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Oct 2024
San Antonio, TX
Jun 24, 2025 at 3:26 AM#14

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Has anyone dealt with.

To answer wei_SG: I started tracking everything in a spreadsheet from day 1.

Quick update: I will post a proper update thread soon. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

Last edited: Jun 24, 2025 at 5:26 AM
39 17LindaRN_retired, tommy_boulder, hyun_seoul and 36 others
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DataDave
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Apr 2024
Washington
Online
Jun 24, 2025 at 3:43 AM#15

Adding my data to this Has anyone dealt with discussion:

MetricBaselineMonth 3Month 8
Weight242 lbs217 lbs207 lbs
A1C6.6%5.8%5.4%
hsCRP6.02.00.8

Protocol: Semaglutide 2.4mg/wk, resistance training 3x/wk, protein 1.4g/kg/day.

37 14Dr.GutHealth, amsterdam_pete, LondonLisa and 34 others
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