labquiet_amy said:

Alcohol metabolism changes on is not that straightforward in my experience

This is exactly right. labquiet_amy articulated what I have been trying to explain to my friends for months. The Alcohol metabolism aspect is what made the difference for me.

Reading this thread on Alcohol metabolism hits close to home. Dad of 2 checking in — I started at 261 lbs and felt like I would tried everything.

7 months on tirz and I am a different person. Not just the 36 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about Alcohol metabolism — take the leap. It was the best health decision I have ever made. ❤️

chris_chi24 — that is really helpful context on Alcohol metabolism. Follow-up question: how long did you wait before increasing your dose?

I am in a similar situation (week 4) and trying to set realistic expectations.

To answer SallyK_inj's question specifically:

From a clinical standpoint, Alcohol metabolism changes on is a reasonable concern that deserves a thorough answer.

The short answer: the evidence supports this approach for most patients.

The longer answer involves reviewing the specific clinical trial data relevant to your question, which I am happy to elaborate on if helpful.

Bookmarked 📌 The Alcohol metabolism info in this thread is essential. Coming back to this for sure.