🍪 CompoundTalk uses cookies to improve your experience, analyze traffic, and personalize content. By continuing to use this site, you agree to our Cookie Policy.
Evidence-based GLP-1 & peptide discussion since 2023
ForumsLab Results & BiomarkersVitamin B12 monitoring — deficiency prevalence on GLP-1 therapy Page 5

Vitamin B12 monitoring — deficiency prevalence on GLP-1 therapy

B12Beth Wed, Mar 4, 2026 at 4:16 PM 22 replies 530 viewsPage 5 of 5
hans_munich
Member
534
2,345
Jul 2024
Munich, DE
Mar 4, 2026 at 11:21 PM#21

DerekSJ_a1c — that is really helpful context on Vitamin B12 monitoring . Follow-up question: what labs did your doctor order to monitor this?

I am in a similar situation (just started) and trying to set realistic expectations.

47 3kevin_tulsa, Dr.PainCLE, mike_mealprep and 44 others
Reply Quote Save Share Report
Dr.NateNeph
VIP Member
2,987
16,234
Dec 2023
Houston, TX
Mar 4, 2026 at 11:38 PM#22

To answer JenPlateau's question specifically:

From a clinical standpoint, Vitamin B12 monitoring is an area where we have good evidence.

The short answer: baseline labs + quarterly monitoring is the standard of care.

The longer answer involves understanding the mechanism of action at the receptor level, which I am happy to elaborate on if helpful.

45 12NauseaFreeNow, SteveThurs, B12Beth and 42 others
Reply Quote Save Share Report
paige_pharma
Member
289
1,234
Sep 2024
Omaha, NE
Mar 4, 2026 at 11:55 PM#23

Thank you hans_munich! This is incredibly helpful. Bookmarking for later. 🙏

43 4adam_van, Dr.SurgeonPGH, rachel_ABQ and 40 others
Reply Quote Save Share Report

Sigma-Aldrich — Research-Grade Standards

Certified reference materials, analytical reagents, and research-grade standards for peptide verification. Trusted by laboratories worldwide.

Shop Reference Standards
DataDave
Senior Member
1,678
8,901
Apr 2024
Washington
Online
Mar 5, 2026 at 12:12 AM#24

Relevant to Vitamin B12 monitoring — here is my latest bloodwork comparison:

Key improvements: A1C 7.6% → 5.5%, triglycerides 233 → 103 mg/dL, hsCRP 8.0 → 0.9 mg/L. All on tirzepatide for 13 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

Last edited: Mar 5, 2026 at 1:12 AM
11 21amsterdam_pete, LondonLisa, mike_nyc and 8 others
Reply Quote Save Share Report
GraceAZ_72
Member
156
678
Jan 2025
Tucson, AZ
Mar 5, 2026 at 12:29 AM#25

Slightly tangential to Vitamin B12 monitoring but hans_munich reminded me — what is the latest on the oral formulations?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

Last edited: Mar 5, 2026 at 4:29 AM
31 16RetaRick_CA, JenPlateau, SallyK_inj and 28 others
Reply Quote Save Share Report
1345

Similar Threads

Optimal lab testing frequency on GLP-1 — evidence-based schedule5 replies
A1C from 7.2 to 5.1 — my bloodwork transformation19 replies
Thyroid function monitoring on GLP-1 — TSH and free T4 trends3 replies
Lipid panel improvements mega-thread — share your numbers19 replies
Liver enzymes trending down on GLP-1 — ALT/AST normalization17 replies
ForumsNewTrendingMembersAccount

Log In

Forgot password?
No account? Register