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Evidence-based GLP-1 & peptide discussion since 2023
ForumsLab Results & BiomarkersUric acid trends on GLP-1 — gout risk reduction data Page 5

Uric acid trends on GLP-1 — gout risk reduction data

Dr.RheumBOS Wed, Feb 25, 2026 at 4:11 PM 21 replies 749 viewsPage 5 of 5
Dr.PathRoch
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Rochester, MN
Feb 25, 2026 at 11:16 PM#21

SallyK_inj — that is really helpful context on Uric acid trends on GLP-1. Follow-up question: what labs did your doctor order to monitor this?

I am in a similar situation (just started) and trying to set realistic expectations.

30 13MikeFit_NJ, InsuranceTom, WendyG_ATL and 27 others
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Dr.NephBHM_UK
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Jun 2024
Birmingham, UK
Feb 25, 2026 at 11:33 PM#22

To answer rick_sfbay's question specifically:

From a clinical standpoint, Uric acid trends on GLP-1 is an area where we have good evidence.

The short answer: baseline labs + quarterly monitoring is the standard of care.

The longer answer involves understanding the mechanism of action at the receptor level, which I am happy to elaborate on if helpful.

10 18EndoResFellow, PharmacoVig_BOS, SurmountFan_IN and 7 others
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CryptoCarl
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May 2024
Arizona
Feb 25, 2026 at 11:50 PM#23

Thank you Dr.PathRoch! This is incredibly helpful. Bookmarking for later. 🙏

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DoseLogDan
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Feb 2025
Montana
Feb 26, 2026 at 12:07 AM#24

Relevant to Uric acid trends on GLP-1 — here is my latest bloodwork comparison:

Key improvements: A1C 8.4% → 5.5%, triglycerides 193 → 93 mg/dL, hsCRP 8.0 → 1.1 mg/L. All on tirzepatide for 9 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

Last edited: Feb 26, 2026 at 1:07 AM
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zoe_NC
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Nov 2024
Charlotte, NC
Feb 26, 2026 at 12:24 AM#25

Slightly tangential to Uric acid trends on GLP-1 but Dr.PathRoch reminded me — what is the latest on the oral formulations?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

Last edited: Feb 26, 2026 at 1:24 AM
15 24mike_mealprep, NicoleRaleigh, james_edin and 12 others
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