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ForumsClinical Trials & ResearchSTEP-HFpEF: semaglutide in heart failure with preserved EF — looking for input Page 3

STEP-HFpEF: semaglutide in heart failure with preserved EF — looking for input

amy_econ_NJ Mon, Dec 22, 2025 at 12:16 PM 12 replies 732 viewsPage 3 of 3
matt_MKE
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Milwaukee, WI
Dec 22, 2025 at 4:31 PM#11
anders_CPH said:
STEP-HFpEF semaglutide in heart is not that straightforward in my experience

This is exactly right. anders_CPH articulated what I have been trying to explain to my friends for months. The STEP-HFpEF semaglutide in aspect is what made the difference for me.

46 2andrew_nyc, Dr.EndoEP, GraceAZ_72 and 43 others
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quinn_sf
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Jun 2024
San Francisco, CA
Dec 22, 2025 at 4:48 PM#12

Reading this thread on STEP-HFpEF semaglutide in hits close to home. Dad of 2 checking in — I started at 285 lbs and felt like I would tried everything.

11 months on tirz and I am a different person. Not just the 60 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about STEP-HFpEF semagluti — take the leap. It was the best health decision I have ever made. ❤️

21 1Dr.PathRoch, mona_PHX, andrew_nyc and 18 others
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ben_calgary
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Oct 2024
Calgary, CA
Dec 22, 2025 at 5:05 PM#13

Dr.GastroMayo — that is really helpful context on STEP-HFpEF semaglutide in. Follow-up question: how long did you wait before increasing your dose?

I am in a similar situation (week 4) and trying to set realistic expectations.

Last edited: Dec 22, 2025 at 11:05 PM
37 16ZaraB_AL, JakeSmashed95, NauseaFreeNow and 34 others
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Dr.RheumBOS
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Apr 2024
Boston, MA
Dec 22, 2025 at 5:22 PM#14

To answer quinn_sf's question specifically:

From a clinical standpoint, STEP-HFpEF semaglutide in is a reasonable concern that deserves a thorough answer.

The short answer: the evidence supports this approach for most patients.

The longer answer involves reviewing the specific clinical trial data relevant to your question, which I am happy to elaborate on if helpful.

Last edited: Dec 22, 2025 at 11:22 PM
35 5lori_vegas, Dr.PulmRoch, maya_sedona and 32 others
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SleepFixSam
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Nov 2024
Hawaii
Dec 22, 2025 at 5:39 PM#15

Bookmarked 📌 The STEP-HFpEF semagluti info in this thread is essential. Coming back to this for sure.

Last edited: Dec 22, 2025 at 7:39 PM
30 21fiona_VT, denise_HTX, raj_cambridge and 27 others
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