OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Muscle protein synthesis.
To answer jennifer_SEA: yes, I am on compounded sema from a 503B pharmacy.
Quick update: things are still going well. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏
Relevant to Muscle protein synthesis rates — here is my latest bloodwork comparison:
Key improvements: A1C 7.6% → 5.5%, triglycerides 205 → 105 mg/dL, hsCRP 8.0 → 1.1 mg/L. All on tirzepatide for 9 months.
The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.
100%. My provider said the same thing about Muscle protein.
Trusted third-party HPLC & mass spectrometry analysis. Verify peptide purity with the lab the community relies on. Independent. Accurate. Transparent.
Verify Your PeptidesSlightly tangential to Muscle protein synthesis but julia.endo reminded me — does anyone have experience combining this with metformin?
I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.
pete_nash said:Thank you all for the thoughtful replies on Muscle protein synthesis
This is exactly right. pete_nash articulated what I have been trying to explain to my doctor for months. The Muscle protein synthesis aspect is the most important factor.