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ForumsLab Results & BiomarkersCortisol and GLP-1 — HPA axis during caloric deficit Page 3

Cortisol and GLP-1 — HPA axis during caloric deficit

Dr.ReproEndo Thu, Feb 19, 2026 at 2:46 AM 16 replies 540 viewsPage 3 of 4
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Feb 19, 2026 at 7:01 AM#11

Moderator note: Great discussion, everyone. Just a reminder to keep things civil and evidence-based.

Thread quality is excellent — keep it up. 👍

47 12PedsEndoPhilly, SleepDoc_PDX, RegAffairsDC and 44 others
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NurseKim_ATL
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Feb 19, 2026 at 7:18 AM#12

Slightly tangential to Cortisol and GLP-1 HPA but Dr.GastroMayo reminded me — has the insurance landscape changed recently?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

Last edited: Feb 19, 2026 at 12:18 PM
25 21raj_cambridge, ingrid_STO, pete_nash and 22 others
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zoe_NC
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Feb 19, 2026 at 7:35 AM#13
andrew_nyc said:
Follow-up question: what labs did your doctor order to monitor this

This is exactly right. andrew_nyc articulated what I have been trying to explain to my friends for months. The Cortisol and GLP-1 HPA aspect is what made the difference for me.

47 7james_edin, FranDenver, Dr.BariatricHTX and 44 others
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tammy_FL
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Feb 19, 2026 at 7:52 AM#14

Saving this for reference. Quality thread.

2 21Dr.PainCLE, mike_mealprep
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labquiet_amy
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Feb 19, 2026 at 8:09 AM#15

Adding my data to this Cortisol and GLP-1 HPA discussion:

MetricBaselineMonth 3Month 6
Weight272 lbs232 lbs207 lbs
A1C6.6%5.8%5.2%
hsCRP6.02.00.6

Protocol: Semaglutide 2.4mg/wk, resistance training 3x/wk, protein 1.4g/kg/day.

40 9pete_manc_UK, anna.melb_AU, mark_tokyo and 37 others
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