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ForumsClinical Trials & ResearchSURMOUNT-MMO: tirzepatide for morbid obesity — anyone have experience? Page 4

SURMOUNT-MMO: tirzepatide for morbid obesity — anyone have experience?

jason_paloalto Sun, Nov 23, 2025 at 8:14 AM 22 replies 986 viewsPage 4 of 5
PharmD_Rodriguez
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Nov 23, 2025 at 1:54 PM#16

Just wanted to say — for anyone reading this SURMOUNT-MMO thread who is feeling discouraged: it gets better. The first month are the hardest. Hang in there. 💪

14 4paul_denver, TinaHashiRN, robert_kc and 11 others
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Dr.EndoEP
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Oct 2024
El Paso, TX
Nov 23, 2025 at 2:11 PM#17

As a pharmacist, I want to add some clinical context to this discussion on SURMOUNT-MMO tirzepatide for morbid.

Building on what TrialTracker_MD said — the evidence base here is robust. The key publications to reference are from the SURMOUNT program[1].

Key clinical points:

  1. Efficacy is dose-dependent and typically requires 4-5 weeks to reach steady state
  2. Side effect profile is predictable and usually manageable with standard protocols
  3. Monitoring should include baseline labs and follow-up at 3-month intervals
  4. Patient education significantly improves outcomes and adherence

Standard disclaimer: this is educational, not individualized medical advice.

References:
[1] See thread title for relevant study identification.
17 17james_edin, FranDenver, Dr.BariatricHTX and 14 others
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DataDave
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Nov 23, 2025 at 2:28 PM#18
PharmD_Rodriguez said:
The first month are the hardest

Gonna push back on this one. SURMOUNT-MMO tirzepatide for morbid is not that straightforward in my experience. I have been on this for 12 months and the reality is messier than the trials suggest.

Don't get me wrong — the medication works. But cost accessibility is a real barrier. We should be honest about that.

16 7LondonLisa, mike_nyc, VendorMark and 13 others
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fiona_glasgow
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Glasgow, UK
Nov 23, 2025 at 2:45 PM#19

This thread is incredible for SURMOUNT-MMO info. Better than most online groups.

43 1JessicaH_TX, KevinCompounds, TirzTom and 40 others
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sophie_paris
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Nov 23, 2025 at 3:02 PM#20

Reading this thread on SURMOUNT-MMO tirzepatide hits close to home. Night shift nurse — I started at 299 lbs and felt like I would tried everything.

15 months on tirz and I am a different person. Not just the 74 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about SURMOUNT-MMO — take the leap. It was the best health decision I have ever made. ❤️

7 13BethLabQueen, ChrisMacros, KetoKyle and 4 others
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