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ForumsClinical Trials & ResearchSURMOUNT-MMO: tirzepatide for morbid obesity — anyone have experience? Page 5

SURMOUNT-MMO: tirzepatide for morbid obesity — anyone have experience?

jason_paloalto Sun, Nov 23, 2025 at 8:14 AM 22 replies 986 viewsPage 5 of 5
B12Beth
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Nov 23, 2025 at 3:19 PM#21

PharmD_Rodriguez — that is really helpful context on SURMOUNT-MMO tirzepatide. Follow-up question: what labs did your doctor order to monitor this?

I am in a similar situation (just started) and trying to set realistic expectations.

32 13GraceAZ_72, carl_compliance, DanielChem_CHI and 29 others
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CarlaRPh_TPA
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Nov 23, 2025 at 3:36 PM#22

To answer sophie_paris's question specifically:

From a clinical standpoint, SURMOUNT-MMO tirzepatide for is an area where we have good evidence.

The short answer: baseline labs + quarterly monitoring is the standard of care.

The longer answer involves understanding the mechanism of action at the receptor level, which I am happy to elaborate on if helpful.

28 23ricardo_MIA, BrianDallas92, labquiet_amy and 25 others
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TomFromTexas
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Nov 23, 2025 at 3:53 PM#23

Thank you B12Beth! This is incredibly helpful. Bookmarking for later. 🙏

19 18Dr.KarenChen, Dr.NateNeph, PharmD_Rodriguez and 16 others
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Dr.GutHealth
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Nov 23, 2025 at 4:10 PM#24

Relevant to SURMOUNT-MMO tirzepatide for — here is my latest bloodwork comparison:

Key improvements: A1C 7.6% → 5.5%, triglycerides 213 → 113 mg/dL, hsCRP 8.0 → 1.3 mg/L. All on tirzepatide for 17 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

26 6Dr.RaviCardio, jennifer_SEA, tyler_CSCS and 23 others
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jim_asheville
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Nov 23, 2025 at 4:27 PM#25

Slightly tangential to SURMOUNT-MMO tirzepatide but B12Beth reminded me — what is the latest on the oral formulations?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

Last edited: Nov 23, 2025 at 7:27 PM
19 23LarryQC_SD, wanda_boise, NurseAsh_DET and 16 others
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