To answer FranDenver's question specifically:

From a clinical standpoint, Has anyone dealt with is an area where we have good evidence.

The short answer: baseline labs + quarterly monitoring is the standard of care.

The longer answer involves understanding the mechanism of action at the receptor level, which I am happy to elaborate on if helpful.

LipidDoc_ATL — that is really helpful context on Has anyone dealt with. Follow-up question: how long did you wait before increasing your dose?

I am in a similar situation (week 4) and trying to set realistic expectations.

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Has anyone dealt with.

To answer claudia_zurich: I started tracking everything in a spreadsheet from day 1.

Quick update: I will post a proper update thread soon. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

Congrats claudia_zurich!! You should be so proud of yourself. 🎉

Can confirm — identical experience.