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ForumsCardiovascular OutcomesSOUL trial preliminary data — November 2025 Page 9

SOUL trial preliminary data — November 2025

JenMemphis Thu, Dec 19, 2024 at 2:50 AM 51 replies 2,130 viewsPage 9 of 11
MeganSA_TX
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Dec 19, 2024 at 3:35 PM#41

TirzTom — that is really helpful context on SOUL trial preliminary. Follow-up question: did you experience any side effects during this phase?

I am in a similar situation (about to start) and trying to set realistic expectations.

25 19PharmD_Rodriguez, julia.endo, JessicaM_2024 and 22 others
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julia.endo
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Dec 19, 2024 at 3:52 PM#42

Want to share my personal experience related to SOUL trial preliminary data since I think it might help others in a similar situation.

I started my GLP-1 journey in March 2025 at 274 lbs with metabolic syndrome. My telehealth provider prescribed semaglutide 0.25mg to start.

Now, 14 months later: I am down 69 lbs, my labs have normalized, and my sleep apnea has improved dramatically. The SOUL trial prelimina aspect specifically was something that made a big difference in my journey.

This forum was my go-to resource throughout.

23 23mark_tokyo, hans_munich, jason_sac26 and 20 others
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jennifer_SEA
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Seattle, WA
Dec 19, 2024 at 4:09 PM#43

Just wanted to say — for anyone reading this SOUL trial prelimina thread who is feeling discouraged: it gets better. The first month are the hardest. Hang in there. 💪

Last edited: Dec 19, 2024 at 10:09 PM
29 17matt_MKE, Dr.ReproEndo, lucas_SP_BR and 26 others
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hyun_seoul
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Seoul, KR
Dec 19, 2024 at 4:26 PM#44

Yep. My endo said the same thing about SOUL trial prelimina.

6 6BariatricNurseD, MASHdoc_SA, GenomicsKate and 3 others
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fiona_glasgow
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Aug 2024
Glasgow, UK
Dec 19, 2024 at 4:43 PM#45

Just wanted to say — for anyone reading this SOUL trial prelimina thread who is feeling discouraged: it gets better. The first 6 weeks are the hardest. Hang in there. 💪

31 3NeuroNate, JessicaH_TX, KevinCompounds and 28 others
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