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ForumsLab Results & BiomarkersLiver enzymes trending down on GLP-1 — 6 month update Page 3

Liver enzymes trending down on GLP-1 — 6 month update

BiostatsBrad Fri, Jan 16, 2026 at 11:37 AM 11 replies 731 viewsPage 3 of 3
emily_PDX
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Jan 16, 2026 at 3:52 PM#11

VanRx_Mike — wow. This community is amazing.

44 13julia.endo, JessicaM_2024, TomFromTexas and 41 others
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oliver_london
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Aug 2024
London, UK
Jan 16, 2026 at 4:09 PM#12

Slightly tangential to Liver enzymes trending but BiostatsBrad reminded me — what is the latest on the oral formulations?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

Last edited: Jan 16, 2026 at 5:09 PM
16 24MikeNYC_runner and 13 others
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patPC_UT
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Park City, UT
Jan 16, 2026 at 4:26 PM#13

Thanks for sharing this, BiostatsBrad. A few questions about your Liver enzymes experience:

  1. What dose did you start at?
  2. How long before you noticed side effects improving?
  3. Did your provider have any specific recommendations about Liver enzymes?

I am in a similar boat and trying to learn from others' experiences before my next appointment.

Last edited: Jan 16, 2026 at 9:26 PM
5 13TomFromTexas, mike.trainer_LA, sarah_nash92 and 2 others
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BiostatsBrad
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Durham, NC
Jan 16, 2026 at 4:43 PM#14

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Liver enzymes trending.

To answer oliver_london: yes, I am on compounded sema from a 503B pharmacy.

Quick update: things are still going well. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

6 6james_edin, FranDenver, Dr.BariatricHTX and 3 others
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HPLC_Greg
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Research Triangle, NC
Jan 16, 2026 at 5:00 PM#15

Relevant to Liver enzymes trending down on — here is my latest bloodwork comparison:

Key improvements: A1C 7.6% → 5.5%, triglycerides 205 → 105 mg/dL, hsCRP 8.0 → 1.1 mg/L. All on tirzepatide for 9 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

Last edited: Jan 16, 2026 at 11:00 PM
13 11SaraMom3, Dr.MetabolicMD, RetaRick_CA and 10 others
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