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ForumsTirzepatide (Mounjaro / Zepbound)Tirzepatide half-life and injection timing — 6 month update Page 2

Tirzepatide half-life and injection timing — 6 month update

NurseLeah_Nash Thu, Oct 3, 2024 at 12:37 AM 11 replies 1,764 viewsPage 2 of 3
PurityPaulOR
Senior Member
1,890
7,890
Mar 2024
Oregon
Oct 3, 2024 at 3:27 AM#6

UPDATE — tried warming + icing:

Took the pen out 30 min early, iced the spot for 3 min before, injected slowly (held 10 seconds), iced for 5 min after, didn't rub.

Result: still got a small lump but it's maybe 60% smaller than usual and the redness cleared by day 2 instead of day 5. HUGE improvement!! Going to keep doing this. Thank you all so much 🙏

45 21Dr.LeslieOBGYN, MikeNYC_runner and 42 others
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laura_annarbor
Member
189
890
Dec 2024
Ann Arbor, MI
Oct 3, 2024 at 3:44 AM#7

Glad that helped! The warming is probably the single biggest factor. That medication is viscous when cold and creates more tissue disruption on injection. Most patients who implement the warming step alone see significant improvement.

20 12emily_PDX, Dr.SleepRoch, laura_annarbor and 17 others
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andrew_nyc
Member
534
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Apr 2024
New York, NY
Oct 3, 2024 at 4:01 AM#8

Great improvement Laura! If the smaller lumps still bother you, a thin layer of OTC hydrocortisone cream on the injection site after the post-injection icing can help with the residual inflammation. Just don't apply it BEFORE injection — you want the area clean and dry pre-injection. 👩‍⚕️

Last edited: Oct 3, 2024 at 9:01 AM
49 15PharmD_Rodriguez, julia.endo, JessicaM_2024 and 46 others
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