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ForumsRetatrutide & Triple AgonistsRetatrutide and fatty liver — MASH resolution rates in Phase 2 Page 5

Retatrutide and fatty liver — MASH resolution rates in Phase 2

MASHdoc_SA Fri, Feb 13, 2026 at 6:13 PM 23 replies 534 viewsPage 5 of 5
MaxMetOK
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Oklahoma
Feb 14, 2026 at 1:18 AM#21

pete_nash — that is really helpful context on Retatrutide and fatty. Follow-up question: what labs did your doctor order to monitor this?

I am in a similar situation (just started) and trying to set realistic expectations.

Last edited: Feb 14, 2026 at 6:18 AM
30 19PharmHunterJen, TomTeleRx, DoseLogDan and 27 others
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MASHdoc_SA
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Aug 2024
San Antonio, TX
Feb 14, 2026 at 1:35 AM#22

To answer BenResearch_OR's question specifically:

From a clinical standpoint, Retatrutide and fatty liver is an area where we have good evidence.

The short answer: baseline labs + quarterly monitoring is the standard of care.

The longer answer involves understanding the mechanism of action at the receptor level, which I am happy to elaborate on if helpful.

Last edited: Feb 14, 2026 at 4:35 AM
15 13TrialTracker_MD, JennaRN, LabKate and 12 others
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carlos_SATX
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Oct 2024
San Antonio, TX
Feb 14, 2026 at 1:52 AM#23

Thank you MaxMetOK! This is incredibly helpful. Bookmarking for later. 🙏

25 0Dr.BariatricHTX, LindaRN_retired, tommy_boulder and 22 others
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jason_paloalto
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Palo Alto, CA
Feb 14, 2026 at 2:09 AM#24

Relevant to Retatrutide and fatty liver — here is my latest bloodwork comparison:

Key improvements: A1C 8.4% → 5.5%, triglycerides 209 → 109 mg/dL, hsCRP 8.0 → 0.9 mg/L. All on tirzepatide for 13 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

38 20andrew_nyc, Dr.EndoEP, GraceAZ_72 and 35 others
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RickReta_CO
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Jan 2025
Colorado
Feb 14, 2026 at 2:26 AM#25

Slightly tangential to Retatrutide and fatty but MaxMetOK reminded me — what is the latest on the oral formulations?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

Last edited: Feb 14, 2026 at 7:26 AM
7 0LindaRN_retired, tommy_boulder, hyun_seoul and 4 others
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