🍪 CompoundTalk uses cookies to improve your experience, analyze traffic, and personalize content. By continuing to use this site, you agree to our Cookie Policy.
Evidence-based GLP-1 & peptide discussion since 2023
ForumsTirzepatide (Mounjaro / Zepbound)Has anyone dealt with tirzepatide and muscle preservation? Page 2

Has anyone dealt with tirzepatide and muscle preservation?

marcus_mpls Mon, Aug 5, 2024 at 4:36 AM 50 replies 2,916 viewsPage 2 of 10
PharmacoVig_BOS
Senior Member
1,567
8,901
Feb 2024
Boston, MA
Aug 5, 2024 at 7:26 AM#6

Nate — 1,200 cal/day is definitely too low, especially if you're male. Please talk to your provider or a dietitian. Under-eating on GLP-1s can cause muscle loss and metabolic adaptation that'll hurt you long-term. We want fat loss, not just weight loss. 💪

Last edited: Aug 5, 2024 at 10:26 AM
16 17amsterdam_pete, LondonLisa, mike_nyc and 13 others
Reply Quote Save Share Report
steve_okc
Member
489
2,123
Jul 2024
Oklahoma City, OK
Aug 5, 2024 at 7:43 AM#7

The energy thing is real and I think it's one of the most underreported benefits of tirz. I track my workouts religiously and my performance has IMPROVED since starting, despite being in a caloric deficit. My lifting numbers went up. That should not happen when you're eating less. There's definitely something pharmacological going on beyond just "eating better."

I've seen some hypotheses that GIP receptor activation in muscle tissue may help preserve or even improve muscle glucose utilization during weight loss. Would love to see more research on this.

32 23JakeSmashed95, NauseaFreeNow, SteveThurs and 29 others
Reply Quote Save Share Report
wei_SG
Member
234
890
Nov 2024
Singapore, SG
Aug 5, 2024 at 8:00 AM#8

Fran that's fascinating. I'm not lifting (yet) but I might start — the energy has to go somewhere right? 😂

Thanks everyone for confirming I'm not losing my mind. Just losing weight and gaining energy. I'll take it!

40 6Dr.MetabolicMD, RetaRick_CA, JenPlateau and 37 others
Reply Quote Save Share Report

PeptideMeter — Independent Peptide Analytics

Community-driven peptide testing and vendor rating platform. Transparent results. Unbiased analysis. Trusted by thousands.

View Results

Similar Threads

SURMOUNT-5: Tirzepatide vs semaglutide head-to-head — full results11 replies
SURPASS 1-5 program: tirzepatide T2DM efficacy data compilation6 replies
Tirzepatide dual agonism: GIP + GLP-1 synergistic mechanism18 replies
5mg → 10mg → 15mg titration — clinical guidance and real-world data8 replies
Zepbound insurance coverage — payer-by-payer breakdown 20268 replies
ForumsNewTrendingMembersAccount

Log In

Forgot password?
No account? Register