Just wanted to say — for anyone reading this NNT for MACE thread who is feeling discouraged: it gets better. The first few weeks are the hardest. Hang in there. 💪

gary_naperville's experience with NNT for MACE prevention resonates deeply with mine. I went through almost the identical process — starting dose, titration timeline, side effects, everything.

The main difference: I started 3 months later. But the overall trajectory has been remarkably similar. Down 34 lbs in 9 months.

One thing I would add that gary_naperville did not mention: the mental health improvements were just as significant.

Saving this for reference. Top-tier content.

As a pharmacist, I want to add some clinical context to this discussion on NNT for MACE prevention July 2024.

Building on what gary_naperville said — the evidence base here is robust. The key publications to reference are from the SURMOUNT program[1].

Key clinical points:

1. Efficacy is dose-dependent and typically requires 4-5 weeks to reach steady state
2. Side effect profile is predictable and usually manageable with standard protocols
3. Monitoring should include baseline labs and follow-up at 3-month intervals
4. Patient education significantly improves outcomes and adherence

Standard disclaimer: this is educational, not individualized medical advice.

Subscribing to this thread. NNT for MACE prevention is exactly what I've been researching. 🙏