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ForumsRetatrutide & Triple AgonistsWill retatrutide be the first to break 25% weight loss in Phase 3? Page 3

Will retatrutide be the first to break 25% weight loss in Phase 3?

Dr.ObesityMed Wed, Feb 11, 2026 at 1:48 AM 23 replies 941 viewsPage 3 of 5
sophie_paris
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Feb 11, 2026 at 6:03 AM#11

mike_nyc — wow. I've been looking for this exact info for weeks.

Last edited: Feb 11, 2026 at 11:03 AM
42 20SallyK_inj, CryptoCarl, MariaRD and 39 others
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CanadaChris
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Feb 11, 2026 at 6:20 AM#12

Slightly tangential to Will retatrutide be the but Dr.ObesityMed reminded me — has anyone else noticed changes in their alcohol tolerance?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

13 14stefan_berlin, Dr.EM_Chicago, pete_RVA and 10 others
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MarkLI_maint
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Feb 11, 2026 at 6:37 AM#13

Thanks for sharing this, Dr.ObesityMed. A few questions about your Will retatrutide be experience:

  1. What dose did you start at?
  2. How long before you noticed side effects improving?
  3. Did your provider have any specific recommendations about Will retatrutid?

I am in a similar boat and trying to learn from others' experiences before my next appointment.

33 11HPLC_Greg, LibrarianMeg, bri_stats and 30 others
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Dr.ObesityMed
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Feb 11, 2026 at 6:54 AM#14

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Will retatrutide be the.

To answer CanadaChris: I get my labs done through Quest every 3 months.

Quick update: my latest labs came back even better. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

1 17PeptideChemSF
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Dr.RaviCardio
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Feb 11, 2026 at 7:11 AM#15

Relevant to Will retatrutide be the first — here is my latest bloodwork comparison:

Key improvements: A1C 7.2% → 5.3%, triglycerides 235 → 105 mg/dL, hsCRP 6.0 → 1.1 mg/L. All on tirzepatide for 15 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

22 1jason_sac26, chris_chi24, tampaLisa73 and 19 others
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