🍪 CompoundTalk uses cookies to improve your experience, analyze traffic, and personalize content. By continuing to use this site, you agree to our Cookie Policy.
Evidence-based GLP-1 & peptide discussion since 2023
ForumsRetatrutide & Triple AgonistsWill retatrutide be the first to break 25% weight loss in Phase 3? Page 4

Will retatrutide be the first to break 25% weight loss in Phase 3?

Dr.ObesityMed Wed, Feb 11, 2026 at 1:48 AM 23 replies 941 viewsPage 4 of 5
lori_vegas
Member
378
1,678
Aug 2024
Las Vegas, NV
Feb 11, 2026 at 7:28 AM#16

Congrats MarkLI_maint!! Keep going — you're doing incredible. 🎉

Last edited: Feb 11, 2026 at 9:28 AM
19 15amy_econ_NJ, bbq_ray_KC, oliver_london and 16 others
Reply Quote Save Share Report
Dr.DermMIA
Member
456
2,123
May 2024
Miami, FL
Feb 11, 2026 at 7:45 AM#17

Dr.ObesityMed's experience with Will retatrutide be the resonates deeply with mine. I went through almost the identical process — starting dose, titration timeline, side effects, everything.

The main difference: I had more GI issues initially. But the overall trajectory has been remarkably similar. Down 37 lbs in 12 months.

One thing I would add that Dr.ObesityMed did not mention: insurance coverage was a major hurdle.

34 14Dr.RenalNash, LipidDoc_ATL, BariatricNurseD and 31 others
Reply Quote Save Share Report
SarahChen_PharmD
VIP Member
4,567
22,341
Dec 2023
San Diego, CA
Feb 11, 2026 at 8:02 AM#18

Bookmarked 📌 The Will retatrutide be info in this thread is essential. Coming back to this for sure.

Last edited: Feb 11, 2026 at 11:02 AM
42 4paul_denver, TinaHashiRN, robert_kc and 39 others
Reply Quote Save Share Report

Sigma-Aldrich — Research-Grade Standards

Certified reference materials, analytical reagents, and research-grade standards for peptide verification. Trusted by laboratories worldwide.

Shop Reference Standards
anders_CPH
Senior Member
1,567
7,234
Feb 2024
Copenhagen, DK
Feb 11, 2026 at 8:19 AM#19

Clinical perspective on Will retatrutide be the first to break:

I have managed over 200 patients on GLP-1 therapy and this topic comes up frequently. What the data shows — and what I see in practice — is that the medication works best as part of a comprehensive approach.

For this specific question, I would recommend: getting comprehensive baseline labs first.

24 15BethLabQueen, ChrisMacros, KetoKyle and 21 others
Reply Quote Save Share Report
BiostatsBrad
Member
456
2,345
Jul 2024
Durham, NC
Feb 11, 2026 at 8:36 AM#20

Subscribing to this thread. Will retatrutide be the is exactly what I've been researching. 🙏

38 21NicoleRaleigh, james_edin, FranDenver and 35 others
Reply Quote Save Share Report

Similar Threads

TRIUMPH-3 topline results — 24.2% body weight loss at 48 weeks10 replies
Retatrutide mechanism: GLP-1/GIP/glucagon triple agonism explained5 replies
Retatrutide Phase 2 dose-response analysis — optimal dose range10 replies
Glucagon receptor agonism and hepatic lipid oxidation — MASH implications13 replies
Retatrutide vs tirzepatide — dual vs triple agonist comparison22 replies
ForumsNewTrendingMembersAccount

Log In

Forgot password?
No account? Register