Congrats NurseAsh_DET!! You should be so proud of yourself. 🎉

Reading this thread on Can we talk about how hits close to home. Dad of 2 checking in — I started at 277 lbs and felt like I would tried everything.

13 months on tirz and I am a different person. Not just the 52 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about Can we talk about — take the leap. It was the best health decision I have ever made. ❤️

As a healthcare provider, I want to add some clinical context to this discussion on Can we talk about how SLOW the FDA is .

Building on what CanadaChris said — the evidence base here is well-established. The key publications to reference are from the SELECT program[1].

Key clinical points:

1. Efficacy is dose-dependent and typically requires 4-5 weeks to reach steady state
2. Side effect profile is predictable and usually manageable with standard protocols
3. Monitoring should include baseline labs and follow-up at 3-month intervals
4. Patient education significantly improves outcomes and adherence

Standard disclaimer: this is educational, not individualized medical advice.

RegAffairsDC — wow. This community is amazing.

Adding my data to this Can we talk about how discussion:

Protocol: Semaglutide 1.7mg/wk, resistance training 3x/wk, protein 1.2g/kg/day.