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ForumsTirzepatide (Mounjaro / Zepbound)5mg doing nothing - should I ask to go up? — anyone have experience?

5mg doing nothing - should I ask to go up? — anyone have experience?

CanadaChris Thu, May 9, 2024 at 2:21 PM 11 replies 2,008 viewsPage 1 of 3
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CanadaChris
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Nov 2024
Toronto, CA
May 9, 2024 at 3:46 PM#1

Update on my situation with 5mg doing nothing - should i — wanted to follow up since some of you asked.

3 weeks since my last post and things have improved significantly. Here is what happened:

Talked to my endo about the concerns raised in my previous thread and they agreed with the community advice.

Full details below. Thanks to everyone who responded last time — your input genuinely made a difference.

21 17Dr.EM_Chicago, pete_RVA, CarlaRPh_TPA and 18 others
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NeuroNate
Senior Member
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Chicago, IL
May 9, 2024 at 4:03 PM#2

CanadaChris's experience with 5mg doing nothing - resonates deeply with mine. I went through almost the identical process — starting dose, titration timeline, side effects, everything.

The main difference: I titrated faster. But the overall trajectory has been remarkably similar. Down 32 lbs in 7 months.

One thing I would add that CanadaChris did not mention: the relationship with food fundamentally changed.

9 16wendy_avl, jason_paloalto, Dr.LeslieOBGYN and 6 others
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NauseaFreeNow
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Aug 2024
Indiana
May 9, 2024 at 4:20 PM#3

Thanks for sharing this, CanadaChris. A few questions about your 5mg doing nothing - experience:

  1. What dose are you currently on?
  2. How long before you noticed significant changes?
  3. Did your doctor have any specific recommendations about 5mg doing nothi?

I am in a similar boat and trying to learn from others' experiences before my next appointment.

15 5Dr.PulmRoch, maya_sedona, stefan_berlin and 12 others
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CanadaChris
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Nov 2024
Toronto, CA
May 9, 2024 at 4:37 PM#4

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on 5mg doing nothing -.

To answer NauseaFreeNow: yes, I am on compounded sema from a 503B pharmacy.

Quick update: things are still going well. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

43 10Dr.PulmRoch, maya_sedona, stefan_berlin and 40 others
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Dr.AddMedPHL
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Philadelphia, PA
May 9, 2024 at 4:54 PM#5

Relevant to 5mg doing nothing - should I — here is my latest bloodwork comparison:

Key improvements: A1C 8.4% → 5.5%, triglycerides 225 → 95 mg/dL, hsCRP 8.0 → 1.3 mg/L. All on tirzepatide for 17 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

Last edited: May 9, 2024 at 6:54 PM
11 20JessicaM_2024, TomFromTexas, mike.trainer_LA and 8 others
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