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Evidence-based GLP-1 & peptide discussion since 2023
ForumsLab Results & BiomarkersCortisol and GLP-1 — need advice Page 3

Cortisol and GLP-1 — need advice

NurseLeah_Nash Fri, Nov 7, 2025 at 8:41 AM 43 replies 1,438 viewsPage 3 of 9
Admin
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Nov 7, 2025 at 12:56 PM#11

Moderator note: Reminder: nothing posted here constitutes medical advice. Consult your healthcare provider.

Tagging this for the weekly digest. 👍

Last edited: Nov 7, 2025 at 4:56 PM
40 12PedsEndoPhilly, SleepDoc_PDX, RegAffairsDC and 37 others
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Dr.ReproEndo
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Nov 7, 2025 at 1:13 PM#12

Clinical perspective on Cortisol and GLP-1 need advice:

I have managed roughly 300 patients on GLP-1 therapy and this topic comes up frequently. What the data shows — and what I see in practice — is that the medication works best as part of a comprehensive approach.

For this specific question, I would recommend: getting comprehensive baseline labs first.

33 18andrew_nyc, Dr.EndoEP, GraceAZ_72 and 30 others
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amsterdam_pete
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Nov 7, 2025 at 1:30 PM#13
Admin said:
Consult your healthcare provider

I respect Admin perspective but I think this oversimplifies things a bit. Re: Cortisol and GLP-1 need — the subgroup analyses show meaningful heterogeneity.

I am not saying Admin wrong entirely — just that the picture is more nuanced than a blanket statement. The STEP data specifically shows dose-dependent variation.

18 21CanadaChris, ZaraB_AL, JakeSmashed95 and 15 others
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InsuranceTom
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Nov 7, 2025 at 1:47 PM#14

Reading this thread on Cortisol and GLP-1 need hits close to home. Night shift nurse — I started at 279 lbs and felt like I would tried everything.

15 months on tirz and I am a different person. Not just the 54 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about Cortisol and GLP-1 — take the leap. It was the best health decision I have ever made. ❤️

Last edited: Nov 7, 2025 at 6:47 PM
27 11matt_MKE, Dr.ReproEndo, lucas_SP_BR and 24 others
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EndoResFellow
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Nov 7, 2025 at 2:04 PM#15

Bookmarked 📌 The Cortisol and GLP-1 info in this thread is essential. Coming back to this for sure.

26 21Dr.ObesityLA, NurseKim_ATL, paul_denver and 23 others
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