Saving this for reference. Quality thread.

Want to share my personal experience related to Cortisol and GLP-1 need since I think it might help others in a similar situation.

I started my GLP-1 journey in October 2024 at 287 lbs with prediabetes and hypertension. My endocrinologist prescribed semaglutide 0.25mg to start.

Now, 6 months later: I am down 57 lbs, my labs have normalized, and I am off 2 of my 3 medications. The Cortisol and GLP-1 aspect specifically was something that made a big difference in my journey.

This community helped me every step of the way.

Relevant to Cortisol and GLP-1 need — here is my latest bloodwork comparison:

Key improvements: A1C 7.6% → 5.5%, triglycerides 233 → 103 mg/dL, hsCRP 8.0 → 0.9 mg/L. All on tirzepatide for 13 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

Want to share my personal experience related to Cortisol and GLP-1 need since I think it might help others in a similar situation.

I started my GLP-1 journey in March 2025 at 259 lbs with metabolic syndrome. My telehealth provider prescribed semaglutide 0.25mg to start.

Now, 12 months later: I am down 64 lbs, my labs have normalized, and my sleep apnea has improved dramatically. The Cortisol and GLP-1 aspect specifically was something that made a big difference in my journey.

This forum was my go-to resource throughout.

wendy_avl — that is really helpful context on Cortisol and GLP-1 need. Follow-up question: did you change anything about your diet at the same time?

I am in a similar situation (month 2) and trying to set realistic expectations.