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ForumsRetatrutide & Triple AgonistsWill reta make sema and tirz obsolete? Page 3

Will reta make sema and tirz obsolete?

andrew_nyc Thu, Jan 8, 2026 at 9:23 AM 33 replies 1,028 viewsPage 3 of 7
anders_CPH
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Jan 8, 2026 at 1:38 PM#11

+1 to HPLC_Greg. Especially the point about "Re: Will reta make sema and tirz — the s..." — I have seen the same in my own experience with Will reta make sema and.

Last edited: Jan 8, 2026 at 5:38 PM
14 1CryptoCarl, MariaRD, AussieAnna and 11 others
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carl_compliance
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Raleigh, NC
Jan 8, 2026 at 1:55 PM#12

Want to share my personal experience related to Will reta make sema and tirz since I think it might help others in a similar situation.

I started my GLP-1 journey in March 2025 at 285 lbs with metabolic syndrome. My telehealth provider prescribed semaglutide 0.25mg to start.

Now, 6 months later: I am down 50 lbs, my labs have normalized, and my sleep apnea has improved dramatically. The Will reta make sema aspect specifically was something that made a big difference in my journey.

This forum was my go-to resource throughout.

3 19BrianDallas92, labquiet_amy, emily_PDX
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traveltech_sara
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Jan 8, 2026 at 2:12 PM#13

NurseKim_ATL — that is really helpful context on Will reta make sema and. Follow-up question: did you change anything about your diet at the same time?

I am in a similar situation (month 2) and trying to set realistic expectations.

Last edited: Jan 8, 2026 at 5:12 PM
23 18wanda_boise, NurseAsh_DET, BenResearch_OR and 20 others
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Dr.BariatricHTX
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Jan 8, 2026 at 2:29 PM#14

To answer carl_compliance's question specifically:

From a clinical standpoint, Will reta make sema and tirz is well-supported by the literature.

The short answer: follow the standard titration protocol and reassess at 4-6 weeks.

The longer answer involves pharmacokinetic considerations around steady-state concentrations, which I am happy to elaborate on if helpful.

26 2stefan_berlin, Dr.EM_Chicago, pete_RVA and 23 others
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LipidDoc_ATL
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Atlanta, GA
Jan 8, 2026 at 2:46 PM#15

Saving this for reference. Top-tier content.

Last edited: Jan 8, 2026 at 7:46 PM
38 2KristenIndy, MarkLI_maint, Dr.PeteFamMed and 35 others
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