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Evidence-based GLP-1 & peptide discussion since 2023
ForumsRetatrutide & Triple AgonistsWill reta make sema and tirz obsolete? Page 4

Will reta make sema and tirz obsolete?

andrew_nyc Thu, Jan 8, 2026 at 9:23 AM 33 replies 1,028 viewsPage 4 of 7
andrew_nyc
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Jan 8, 2026 at 3:03 PM#16

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Will reta make sema and.

To answer carl_compliance: I get my labs done through Quest every 3 months.

Quick update: my latest labs came back even better. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

29 19Dr.KarenChen, Dr.NateNeph, PharmD_Rodriguez and 26 others
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SleepDoc_PDX
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Jan 8, 2026 at 3:20 PM#17

Relevant to Will reta make sema and tirz — here is my latest bloodwork comparison:

Key improvements: A1C 7.2% → 5.3%, triglycerides 235 → 105 mg/dL, hsCRP 6.0 → 1.1 mg/L. All on tirzepatide for 15 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

Last edited: Jan 8, 2026 at 6:20 PM
33 15hank_denver, carlos_SATX, sophie_paris and 30 others
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Dr.NutriCornell
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Jan 8, 2026 at 3:37 PM#18

Yep. My endo said the same thing about Will reta make sema.

16 22laura_annarbor, JenMemphis, pat_auckland and 13 others
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JennaRN
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Jan 8, 2026 at 3:54 PM#19

Slightly tangential to Will reta make sema and but anders_CPH reminded me — has the insurance landscape changed recently?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

46 20RegAffairsDC, BiostatsBrad, PeptideSynthNJ and 43 others
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Dr.LeslieOBGYN
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Jan 8, 2026 at 4:11 PM#20
andrew_nyc said:
Thank you all for the thoughtful replies on Will reta make sema and

This is exactly right. andrew_nyc articulated what I have been trying to explain to my friends for months. The Will reta make sema and aspect is what made the difference for me.

5 7mike_mealprep, NicoleRaleigh, james_edin and 2 others
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