Can confirm — same results here.

Dr.ObesityMed said:

I started my GLP-1 journey in October 2024 at 280 lbs with prediabetes and hypertension

Gonna push back on this one. Will reta make sema and tirz is not that straightforward in my experience. I have been on this for 18 months and the reality is messier than the trials suggest.

Don't get me wrong — the medication works. But adherence is harder than people admit. We should be honest about that.

Want to share my personal experience related to Will reta make sema and tirz since I think it might help others in a similar situation.

I started my GLP-1 journey in March 2025 at 286 lbs with metabolic syndrome. My telehealth provider prescribed semaglutide 0.25mg to start.

Now, 12 months later: I am down 51 lbs, my labs have normalized, and my sleep apnea has improved dramatically. The Will reta make sema aspect specifically was something that made a big difference in my journey.

This forum was my go-to resource throughout.

Saving this for reference. Quality thread.

nick_SD_fit — that is really helpful context on Will reta make sema and. Follow-up question: how long did you wait before increasing your dose?

I am in a similar situation (week 4) and trying to set realistic expectations.