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Evidence-based GLP-1 & peptide discussion since 2023
ForumsRetatrutide & Triple AgonistsWill reta make sema and tirz obsolete? Page 7

Will reta make sema and tirz obsolete?

andrew_nyc Thu, Jan 8, 2026 at 9:23 AM 33 replies 1,028 viewsPage 7 of 7
lisa_labSD
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Jan 8, 2026 at 7:18 PM#31

To answer SleepDoc_PDX's question specifically:

From a clinical standpoint, Will reta make sema and tirz is a reasonable concern that deserves a thorough answer.

The short answer: the evidence supports this approach for most patients.

The longer answer involves reviewing the specific clinical trial data relevant to your question, which I am happy to elaborate on if helpful.

Last edited: Jan 8, 2026 at 10:18 PM
19 19stefan_berlin, Dr.EM_Chicago, pete_RVA and 16 others
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lori_vegas
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Jan 8, 2026 at 7:35 PM#32

Congrats andrew_nyc!! You should be so proud of yourself. 🎉 👏

Last edited: Jan 8, 2026 at 9:35 PM
15 1bbq_ray_KC, oliver_london, tane_welly and 12 others
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andrew_nyc
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Jan 8, 2026 at 7:52 PM#33

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Will reta make sema and.

To answer andrew_nyc: my doctor and I discussed the options and went with brand.

Quick update: I have noticed more improvement since posting this. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

Last edited: Jan 9, 2026 at 12:52 AM
12 6PharmD_Rodriguez, julia.endo, JessicaM_2024 and 9 others
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mike_mod
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Jan 8, 2026 at 8:09 PM#34

Congrats andrew_nyc!! Keep going — you're doing incredible. 🎉

5 14SleepFixSam, PurityPaulOR, MaxMetOK and 2 others
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ZaraB_AL
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Jan 8, 2026 at 8:26 PM#35

This thread is incredible for Will reta make sema info. Better than most online groups.

20 10JennaRN, LabKate, kate.chem and 17 others
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