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Evidence-based GLP-1 & peptide discussion since 2023
ForumsTirzepatide (Mounjaro / Zepbound)My appetite is literally gone is this normal at 10mg — November 2025

My appetite is literally gone is this normal at 10mg — November 2025

PeptideSynthNJ Mon, Mar 4, 2024 at 7:10 AM 45 replies 2,266 viewsPage 1 of 9
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PeptideSynthNJ
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Mar 4, 2024 at 8:35 AM#1

My appetite is literally gone is this normal at 10mg — November 2025

Wanted to share some data with the community since I know we're all about evidence here.

Background: I have been tracking everything meticulously since starting tirz 12 months ago. Here's what I have found regarding my appetite is literally gone is.

I'll post my numbers below and would love to see others share theirs too. The more data points we have, the better we can all make informed decisions.

Fair warning — this is a long post. TL;DR at the bottom for those who do not want the full breakdown.

20 15wanda_boise, NurseAsh_DET, BenResearch_OR and 17 others
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Dr.SurgeonPGH
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Pittsburgh, PA
Mar 4, 2024 at 8:52 AM#2

To answer the question about My appetite is literally gone is this normal at 10mg November 2025 — in my experience this comes down to a few key factors.

I have been dealing with this for several months now, and what I have found is that individual responses really do vary. That said, the general consensus on My appetite is literally gone seems solid.

What specifically worked for me: tracking everything in a spreadsheet. I would suggest PeptideSynthNJ try the same approach and reporting back.

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Dr.LeslieOBGYN
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Mar 4, 2024 at 9:09 AM#3
Dr.SurgeonPGH said:
I have been dealing with this for several months now, and what I have found is that individual respo

Completely agree with Dr.SurgeonPGH. I would add that My appetite is literally gone also has implications for body composition that sometimes get overlooked in these discussions.

In my case, following a similar approach led to fewer side effects compared to what I was doing before.

Last edited: Mar 4, 2024 at 3:09 PM
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paul_denver
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Mar 4, 2024 at 9:26 AM#4

Subscribing to this thread. My appetite is literally is exactly what I've been researching. 🙏

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PharmHunterJen
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Mar 4, 2024 at 9:43 AM#5

As a healthcare provider, I want to add some clinical context to this discussion on My appetite is literally gone is this.

Building on what PeptideSynthNJ said — the evidence base here is well-established. The key publications to reference are from the FLOW program[1].

Key clinical points:

  1. Efficacy is dose-dependent and typically requires 4-5 weeks to reach steady state
  2. Side effect profile is predictable and usually manageable with standard protocols
  3. Monitoring should include baseline labs and follow-up at 3-month intervals
  4. Patient education significantly improves outcomes and adherence

Standard disclaimer: this is educational, not individualized medical advice.

References:
[1] See thread title for relevant study identification.
Last edited: Mar 4, 2024 at 3:43 PM
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