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Evidence-based GLP-1 & peptide discussion since 2023
ForumsTirzepatide (Mounjaro / Zepbound)My appetite is literally gone is this normal at 10mg — November 2025 Page 3

My appetite is literally gone is this normal at 10mg — November 2025

PeptideSynthNJ Mon, Mar 4, 2024 at 7:10 AM 45 replies 2,266 viewsPage 3 of 9
Dr.GastroMayo
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Mar 4, 2024 at 11:25 AM#11
mike.trainer_LA said:
My appetite is literally gone is is not that straightforward in my experience

This is exactly right. mike.trainer_LA articulated what I have been trying to explain to my friends for months. The My appetite is literally aspect is what made the difference for me.

50 12mike_nyc, VendorMark, COA_Karl and 47 others
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claudia_zurich
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Mar 4, 2024 at 11:42 AM#12

Reading this thread on My appetite is literally hits close to home. Dad of 2 checking in — I started at 281 lbs and felt like I would tried everything.

7 months on tirz and I am a different person. Not just the 56 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about My appetite is — take the leap. It was the best health decision I have ever made. ❤️

26 22tammy_FL, Dr.LipidDallas, alex_tucson and 23 others
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Dr.EM_Chicago
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Chicago, IL
Mar 4, 2024 at 11:59 AM#13

PharmHunterJen — that is really helpful context on My appetite is literally. Follow-up question: how long did you wait before increasing your dose?

I am in a similar situation (week 4) and trying to set realistic expectations.

49 12Dr.ReproEndo, lucas_SP_BR, lisa_labSD and 46 others
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Dr.MetabolicMD
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Mar 4, 2024 at 12:16 PM#14

To answer claudia_zurich's question specifically:

From a clinical standpoint, My appetite is literally gone is a reasonable concern that deserves a thorough answer.

The short answer: the evidence supports this approach for most patients.

The longer answer involves reviewing the specific clinical trial data relevant to your question, which I am happy to elaborate on if helpful.

23 14Dr.ObesityMed, HealthEcon_DC, PedsEndoPhilly and 20 others
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JenPlateau
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Mar 4, 2024 at 12:33 PM#15

Bookmarked 📌 The My appetite is info in this thread is essential. Coming back to this for sure.

8 24sarah_nash92, FitDadDave, RunnerRach and 5 others
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