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Evidence-based GLP-1 & peptide discussion since 2023
ForumsTirzepatide (Mounjaro / Zepbound)My appetite is literally gone is this normal at 10mg — November 2025 Page 5

My appetite is literally gone is this normal at 10mg — November 2025

PeptideSynthNJ Mon, Mar 4, 2024 at 7:10 AM 45 replies 2,266 viewsPage 5 of 9
sarah_TO
Member
278
1,234
Sep 2024
Toronto, CA
Mar 4, 2024 at 2:15 PM#21

Congrats PeptideSynthNJ!! Keep going — you're doing incredible. 🎉

Last edited: Mar 4, 2024 at 6:15 PM
5 5andrew_nyc, Dr.EndoEP, GraceAZ_72 and 2 others
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MariaRD
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4,567
Jun 2024
New Mexico
Mar 4, 2024 at 2:32 PM#22

Reading this thread on My appetite is literally hits close to home. Night shift nurse — I started at 271 lbs and felt like I would tried everything.

7 months on tirz and I am a different person. Not just the 46 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about My appetite is — take the leap. It was the best health decision I have ever made. ❤️

30 0anders_CPH, Dr.NutriCornell, pam_stl and 27 others
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TinaHashiRN
Member
345
1,567
Sep 2024
Raleigh, NC
Mar 4, 2024 at 2:49 PM#23

As a pharmacist, I want to add some clinical context to this discussion on My appetite is literally gone is this.

Building on what sarah_TO said — the evidence base here is robust. The key publications to reference are from the SUSTAIN program[1].

Key clinical points:

  1. Efficacy is dose-dependent and typically requires 4-5 weeks to reach steady state
  2. Side effect profile is predictable and usually manageable with standard protocols
  3. Monitoring should include baseline labs and follow-up at 3-month intervals
  4. Patient education significantly improves outcomes and adherence

Standard disclaimer: this is educational, not individualized medical advice.

References:
[1] See thread title for relevant study identification.
Last edited: Mar 4, 2024 at 8:49 PM
20 23Dr.Martinez, mike_mod, SarahChen_PharmD and 17 others
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FitDadDave
Member
534
2,678
Jul 2024
Minneapolis, MN
Mar 4, 2024 at 3:06 PM#24

MariaRD — wow. I've been looking for this exact info for weeks.

Last edited: Mar 4, 2024 at 6:06 PM
41 3wendy_avl, jason_paloalto, Dr.LeslieOBGYN and 38 others
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HPLC_Greg
Senior Member
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8,901
Feb 2024
Research Triangle, NC
Mar 4, 2024 at 3:23 PM#25

Adding my data to this My appetite is literally discussion:

MetricBaselineMonth 5Month 6
Weight264 lbs229 lbs209 lbs
A1C6.8%6.0%5.2%
hsCRP8.04.00.6

Protocol: Semaglutide 1.7mg/wk, resistance training 3x/wk, protein 1.6g/kg/day.

17 22SaraMom3, Dr.MetabolicMD, RetaRick_CA and 14 others
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