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Evidence-based GLP-1 & peptide discussion since 2023
ForumsTirzepatide (Mounjaro / Zepbound)SURPASS 1-5 program: tirzepatide T2DM efficacy data compilation — anyone have experience? Page 2

SURPASS 1-5 program: tirzepatide T2DM efficacy data compilation — anyone have experience?

tampaLisa73 Tue, Jan 23, 2024 at 12:37 AM 7 replies 2,013 viewsPage 2 of 2
MikeKY_noInsulin
Member
267
1,234
Oct 2024
Louisville, KY
Jan 23, 2024 at 3:27 AM#6

Nate — 1,200 cal/day is definitely too low, especially if you're male. Please talk to your provider or a dietitian. Under-eating on GLP-1s can cause muscle loss and metabolic adaptation that'll hurt you long-term. We want fat loss, not just weight loss. 💪

Last edited: Jan 23, 2024 at 6:27 AM
9 14sean_dublin, hannah_MT, Dr.SportsMedIN and 6 others
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MikeFit_NJ
Senior Member
1,567
6,543
Apr 2024
New Jersey
Jan 23, 2024 at 3:44 AM#7

The energy thing is real and I think it's one of the most underreported benefits of tirz. I track my workouts religiously and my performance has IMPROVED since starting, despite being in a caloric deficit. My lifting numbers went up. That should not happen when you're eating less. There's definitely something pharmacological going on beyond just "eating better."

I've seen some hypotheses that GIP receptor activation in muscle tissue may help preserve or even improve muscle glucose utilization during weight loss. Would love to see more research on this.

23 9marcus_mpls, DeniseRN_TPA, SandraNC_45 and 20 others
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rick_sfbay
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289
1,234
Jan 2025
San Francisco, CA
Jan 23, 2024 at 4:01 AM#8

Fran that's fascinating. I'm not lifting (yet) but I might start — the energy has to go somewhere right? 😂

Thanks everyone for confirming I'm not losing my mind. Just losing weight and gaining energy. I'll take it!

29 8james_edin, FranDenver, Dr.BariatricHTX and 26 others
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