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Evidence-based GLP-1 & peptide discussion since 2023
ForumsTirzepatide (Mounjaro / Zepbound)Has anyone dealt with tirzepatide dual agonism: gip + glp-1 synergistic mechanism? Page 2

Has anyone dealt with tirzepatide dual agonism: gip + glp-1 synergistic mechanism?

robert_kc Tue, Jan 9, 2024 at 12:28 AM 49 replies 2,765 viewsPage 2 of 10
josh_phd_bmore
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Baltimore, MD
Jan 9, 2024 at 3:18 AM#6

Nate — 1,200 cal/day is definitely too low, especially if you're male. Please talk to your provider or a dietitian. Under-eating on GLP-1s can cause muscle loss and metabolic adaptation that'll hurt you long-term. We want fat loss, not just weight loss. 💪

Last edited: Jan 9, 2024 at 5:18 AM
30 5NurseKim_ATL, paul_denver, TinaHashiRN and 27 others
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CanadaChris
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Nov 2024
Toronto, CA
Jan 9, 2024 at 3:35 AM#7

The energy thing is real and I think it's one of the most underreported benefits of tirz. I track my workouts religiously and my performance has IMPROVED since starting, despite being in a caloric deficit. My lifting numbers went up. That should not happen when you're eating less. There's definitely something pharmacological going on beyond just "eating better."

I've seen some hypotheses that GIP receptor activation in muscle tissue may help preserve or even improve muscle glucose utilization during weight loss. Would love to see more research on this.

50 15stefan_berlin, Dr.EM_Chicago, pete_RVA and 47 others
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PharmD_Rodriguez
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Jan 2024
Miami, FL
Jan 9, 2024 at 3:52 AM#8

Fran that's fascinating. I'm not lifting (yet) but I might start — the energy has to go somewhere right? 😂

Thanks everyone for confirming I'm not losing my mind. Just losing weight and gaining energy. I'll take it!

49 18robert_kc, dan_philly, MeganSA_TX and 46 others
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