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Evidence-based GLP-1 & peptide discussion since 2023
ForumsTirzepatide (Mounjaro / Zepbound)Has anyone dealt with tirzepatide dual agonism: gip + glp-1 synergistic mechanism? Page 3

Has anyone dealt with tirzepatide dual agonism: gip + glp-1 synergistic mechanism?

robert_kc Tue, Jan 9, 2024 at 12:28 AM 49 replies 2,765 viewsPage 3 of 10
NurseLeah_Nash
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Sep 2024
Nashville, TN
Jan 9, 2024 at 4:43 AM#11

Thank you HPLC_Greg! This is incredibly helpful. Taking this to my next appointment. 🙏

15 13RegAffairsDC, BiostatsBrad, PeptideSynthNJ and 12 others
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A1cHero_PHX
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Jul 2024
Phoenix, AZ
Jan 9, 2024 at 5:00 AM#12

Slightly tangential to Has anyone dealt with but robert_kc reminded me — does anyone have experience combining this with metformin?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

Last edited: Jan 9, 2024 at 10:00 AM
15 18KarenAZ_mom, zoe_NC, Dr.ObesityLA and 12 others
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PharmHunterJen
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Jul 2024
Illinois
Jan 9, 2024 at 5:17 AM#13

Thanks for sharing this, robert_kc. A few questions about your Has anyone dealt experience:

  1. What dose did you start at?
  2. How long before you noticed side effects improving?
  3. Did your provider have any specific recommendations about Has anyone deal?

I am in a similar boat and trying to learn from others' experiences before my next appointment.

17 1kevin_tulsa, Dr.PainCLE, mike_mealprep and 14 others
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robert_kc
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Oct 2024
Kansas City, MO
Jan 9, 2024 at 5:34 AM#14

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Has anyone dealt with.

To answer A1cHero_PHX: I started tracking everything in a spreadsheet from day 1.

Quick update: I will post a proper update thread soon. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

3 4TomTeleRx, DoseLogDan, SleepFixSam
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anders_CPH
Senior Member
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Feb 2024
Copenhagen, DK
Jan 9, 2024 at 5:51 AM#15

Adding my data to this Has anyone dealt with discussion:

MetricBaselineMonth 3Month 8
Weight254 lbs224 lbs219 lbs
A1C6.8%5.8%5.4%
hsCRP8.02.01.2

Protocol: Semaglutide 2.4mg/wk, resistance training 3x/wk, protein 1.6g/kg/day.

34 7ChrisMacros, KetoKyle, CanadaChris and 31 others
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