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Evidence-based GLP-1 & peptide discussion since 2023
ForumsCardiovascular OutcomesHeart rate increase on GLP-1 — November 2025 Page 3

Heart rate increase on GLP-1 — November 2025

Dr.ObesityMed Mon, Mar 4, 2024 at 5:58 AM 31 replies 2,498 viewsPage 3 of 7
tony_orlando
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Nov 2024
Orlando, FL
Mar 4, 2024 at 10:13 AM#11
DanielChem_CHI said:
Heart rate increase on GLP-1 is not that straightforward in my experience

This is exactly right. DanielChem_CHI articulated what I have been trying to explain to my friends for months. The Heart rate increase on aspect is what made the difference for me.

43 16NauseaFreeNow, SteveThurs, B12Beth and 40 others
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RetaRick_CA
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Jan 2024
California
Mar 4, 2024 at 10:30 AM#12

Reading this thread on Heart rate increase on hits close to home. Dad of 2 checking in — I started at 269 lbs and felt like I would tried everything.

15 months on tirz and I am a different person. Not just the 44 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about Heart rate increase — take the leap. It was the best health decision I have ever made. ❤️

34 3AmyNC_wife, SkepticalSean, Dr.CardioMD and 31 others
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TomFromTexas
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May 2024
Austin, TX
Mar 4, 2024 at 10:47 AM#13

LibrarianMeg — that is really helpful context on Heart rate increase on. Follow-up question: how long did you wait before increasing your dose?

I am in a similar situation (week 4) and trying to set realistic expectations.

Last edited: Mar 4, 2024 at 12:47 PM
46 16Dr.KarenChen, Dr.NateNeph, PharmD_Rodriguez and 43 others
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NurseLeah_Nash
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Sep 2024
Nashville, TN
Mar 4, 2024 at 11:04 AM#14

To answer RetaRick_CA's question specifically:

From a clinical standpoint, Heart rate increase on GLP-1 is a reasonable concern that deserves a thorough answer.

The short answer: the evidence supports this approach for most patients.

The longer answer involves reviewing the specific clinical trial data relevant to your question, which I am happy to elaborate on if helpful.

4 12Dr.KarenChen, Dr.NateNeph, PharmD_Rodriguez and 1 other
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JakeBK_lifts
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Jul 2024
Brooklyn, NY
Mar 4, 2024 at 11:21 AM#15

Bookmarked 📌 The Heart rate increase info in this thread is essential. Coming back to this for sure.

49 9DataDave, Dr.GutHealth, amsterdam_pete and 46 others
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