To answer kevin_tulsa's question specifically:

From a clinical standpoint, Heart rate increase on GLP-1 is something I discuss with patients regularly.

The short answer: discuss this specific situation with your prescribing provider.

The longer answer involves weighing the risk-benefit ratio for your individual situation, which I am happy to elaborate on if helpful.

Slightly tangential to Heart rate increase on but CryptoCarl reminded me — does anyone have experience combining this with metformin?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Heart rate increase on.

To answer Dr.ObesityMed: yes, I am on compounded sema from a 503B pharmacy.

Quick update: things are still going well. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

Slightly tangential to Heart rate increase on but julia.endo reminded me — has the insurance landscape changed recently?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

Following this thread closely. Heart rate increase on is something I'm actively working through.