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ForumsTirzepatide (Mounjaro / Zepbound)5mg → 10mg → 15mg titration — looking for input Page 2

5mg → 10mg → 15mg titration — looking for input

MikeKY_noInsulin Mon, Dec 25, 2023 at 9:19 PM 30 replies 2,350 viewsPage 2 of 6
josh_phd_bmore
Member
389
1,678
Jul 2024
Baltimore, MD
Dec 26, 2023 at 12:09 AM#6

This is why I tell everyone: the tortoise wins this race. I did 0.25mg for 5 weeks, 0.5mg for 6 weeks, and I'm now 4 weeks into 1.0mg. Zero nausea at any point. My total weight loss is slower than some people here but I've never had a miserable day on this medication. The titration schedule is your friend.

46 15NurseKim_ATL, paul_denver, TinaHashiRN and 43 others
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KetoKyle
Member
678
3,456
Jul 2024
Utah
Dec 26, 2023 at 12:26 AM#7
Previously posted:
I will absolutely be going back to 0.5mg next week and I will NOT skip ahead again.

Glad you're feeling better. One more thing to keep in mind — when you do eventually go back to 1.0mg (after 4+ weeks at 0.5mg), the transition should be much smoother because:

  1. Your GI receptors will have had proper time to desensitize at the 0.5mg level
  2. You'll have a higher steady-state baseline from consistent 0.5mg dosing
  3. The relative increase from 0.5→1.0 is a 2x jump, which is the largest percentage jump in the standard titration. After that, 1.0→1.7 is 1.7x and 1.7→2.4 is 1.4x

Some providers even add an intermediate 0.75mg step between 0.5 and 1.0 for patients who are particularly sensitive. Worth discussing if you're worried about a repeat experience.

48 2JenMemphis, pat_auckland, Dr.GastroMayo and 45 others
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Dr.KarenChen
VIP Member
4,210
24,567
Nov 2023
San Francisco, CA
Dec 26, 2023 at 12:43 AM#8

The 0.75mg intermediate step is a great idea. I'll ask my provider. Thanks for the advice, you're a lifesaver on this forum. 🙌

3 18TomFromTexas, mike.trainer_LA, sarah_nash92
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