Trying to decide between options regarding soul trial preliminary data what worked and could use some input from people who have been there.

My situation: been on sema for 6 months considering a switch.

I have read the wiki and FAQ but real-world experiences would help me make a decision. What would you do in my position?

Dr.KarenChen's experience with SOUL trial preliminary resonates deeply with mine. I went through almost the identical process — starting dose, titration timeline, side effects, everything.

The main difference: I started 3 months later. But the overall trajectory has been remarkably similar. Down 66 lbs in 11 months.

One thing I would add that Dr.KarenChen did not mention: the mental health improvements were just as significant.

Thanks for sharing this, Dr.KarenChen. A few questions about your SOUL trial prelimina experience:

1. What dose are you currently on?
2. How long before you noticed significant changes?
3. Did your doctor have any specific recommendations about SOUL trial prel?

I am in a similar boat and trying to learn from others' experiences before my next appointment.

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on SOUL trial preliminary.

To answer Dr.ObesityLA: I get my labs done through Quest every 3 months.

Quick update: my latest labs came back even better. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

Relevant to SOUL trial preliminary data — here is my latest bloodwork comparison:

Key improvements: A1C 7.2% → 5.3%, triglycerides 219 → 119 mg/dL, hsCRP 6.0 → 1.3 mg/L. All on tirzepatide for 11 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.