NeuroNate said:

Arterial stiffness reduction on is not that straightforward in my experience

This is exactly right. NeuroNate articulated what I have been trying to explain to my friends for months. The Arterial stiffness aspect is what made the difference for me.

Reading this thread on Arterial stiffness hits close to home. Dad of 2 checking in — I started at 277 lbs and felt like I would tried everything.

13 months on tirz and I am a different person. Not just the 52 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about Arterial stiffness — take the leap. It was the best health decision I have ever made. ❤️

Dr.Martinez — that is really helpful context on Arterial stiffness. Follow-up question: how long did you wait before increasing your dose?

I am in a similar situation (week 4) and trying to set realistic expectations.

To answer pete_nash's question specifically:

From a clinical standpoint, Arterial stiffness reduction is a reasonable concern that deserves a thorough answer.

The short answer: the evidence supports this approach for most patients.

The longer answer involves reviewing the specific clinical trial data relevant to your question, which I am happy to elaborate on if helpful.

Bookmarked 📌 The Arterial stiffness info in this thread is essential. Coming back to this for sure.